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REVIEW OF CELL FUNCTIONS. Metabolism: catabolism, anabolism. Metabolism - the processes by which cells synthesize biomolecules and generate energy Catabolism : the process of breaking down larger molecules to extract energy and create reaction substrates.

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Presentation Transcript
metabolism catabolism anabolism
Metabolism: catabolism, anabolism
  • Metabolism- the processes by which cells synthesize biomolecules and generate energy
    • Catabolism: the process of breaking down larger molecules to extract energy and create reaction substrates.
    • Anabolism: the process of synthesizing larger molecules for maintenance and new cell generation.
bioenergetics atp
Bioenergetics: ATP
  • Cells require energy for synthesis, transport, motility, signaling
  • Energy in cells is transferred largely through ATP (adenosine triphosphate).
phosphate bond energy
Phosphate bond energy

Free energy change of reaction

ATP is regenerated from ADP when phosphate bonds in other compounds undergo hydrolysis in metabolism or in respiration.

nad p nad p h
NAD(P)+/NAD(P)H
  • Nicotinamide adenine dinucleotide
  • Nicotinamide adenine dinucleotide phospate
  • Electron donor/receptor for oxidation-reduction reactions
    • Provides reducing power (hydrogen atoms) for biosynthetic processes
    • Provides electrons for ATP formation in respiration
oxidative phosphorylation
Oxidative Phosphorylation
  • The process by which ATP is formed as a result of the transfer of electrons from NADH or FADH2 to O2 by a series of electron carriers.
  • Occurs via the electron transport chain (proton gradient).
  • The major source of ATP for aerobic organisms.
electron transport chain
Electron Transport Chain
  • Composed of two coupled functions
    • Transfer of electrons from NADH or FADH2
    • Use of protons to phosphorylate ADP to ATP
electron transport chain1
Electron Transport Chain

http://www.sp.uconn.edu/~terry/images/anim/ATPmito.html

atp generation
ATP Generation

http://www.sp.uconn.edu/~terry/images/anim/ATPmito.html

slide14

Aerobic CatabolismGlycolysis/EMPGlucose  pyruvateTCA Cycle/Krebs/Citric Acidpyruvate  CO2 + NADHElectron Transport ChainO2H2O H+ ADP ATPNADH  NAD gradient…….…………..

glucose metabolism
Glucose Metabolism
  • Three major pathways: hexose monophosphate (HMP, also called pentose phosphate), Entner-Doudoroff: (ED),and Embden-Meyerhof-Parnas (EMP, also called glycolysis)
  • Primary pathway is EMP, an anaerobic pathway that terminates with the production of pyruvate
net reaction
Net Reaction
  • For each glucose molecule, two molecules of ATP are regenerated and 2 molecules of pyruvate are produced.
utilization of pyruvate
Utilization of pyruvate
  • Aerobic- pyruvate enters TCA cycle producing CO2 and NADH.
  • Anaerobic- pyruvate is converted to ethanol, lactic acid, acetone, butanol and/or acetic acid (original definition of fermentation)
tca cycle
TCA Cycle
  • Called the tricarboxylic acid (TCA) cycle, Krebs cycle, or citric acid cycle
  • Pyruvate undergoes oxidative decarboxylation with coenzyme A (CoA) to form acetyl-CoA, the immediate precursor for the TCA cycle
tca cycle highlights
TCA Cycle Highlights
  • Two carbon atoms enter cycle
  • Four pairs of hydrogen atoms leave the cycle in four oxidative reactions
  • One high energy phosphate bond is formed (GTP)
  • Two water molecules are consumed
  • NADH formed is used as reducing power to generate ATP in electron transport chain
net reaction1
Net Reaction
  • GTP is used as a phosphoryl donor in protein synthesis and signal transduction processes, or is easily interchangeable with ATP
production of biosynthetic precursors by the tca cycle
Production of Biosynthetic Precursors by the TCA Cycle

TCA cycle inter-mediates can be funneled off for biosynthesis

replenishing intermediates
Replenishing Intermediates
  • These intermediates are replaced by anaplerotic reactions (Greek “to fill up”)
  • Cells can also “fix” CO2 to replace intermediates (heterotropic CO2 fixation). Growth rate can actually be limited by CO2 availability.
anaerobic alternatives
Anaerobic Alternatives
  • Anaerobic respiration can occur by using nitrate as a terminal electron acceptor in the electron transport chain
  • Many cell can also generate energy without the electron transport chain, but with a lower efficiency.
alcohol and lactate formation
Alcohol and Lactate Formation

No net oxidation or reduction since electron transport chain is not available to produce NAD+ required in TCA cycle

pentose phosphate pathway
Pentose Phosphate Pathway

Generates NADPH (reducing power for for biosynthesis) and 5 carbon sugars (make up ATP, RNA, DNA, others)

pathways
Pathways
  • Many pathways have been elucidated. We have discussed a few of the more common.