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Histologic Findings of Villous Adenoma in Colonic Mucosa

A 50-year-old man underwent sigmoidoscopy for GI pathology evaluation. The findings revealed a benign neoplasm known as a Villous Adenoma characterized by finger-like mucosal projections. The epithelium lining the villi showed dysplastic changes with enlarged, hyperchromatic cells. The adjacent mucosa appeared normal.

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Histologic Findings of Villous Adenoma in Colonic Mucosa

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  1. GI Pathology II, Case 5 • 50-year-old man has sigmoidoscopy to evaluate for GI pathology

  2. A Villous Adenoma B Tubular Adenoma

  3. Describe the histologic findings. Diagnosis?

  4. Villous adenoma Normal colonic mucosa Villous Adenoma A low power view of the colonic mucosa revelas a benign neoplasm composed of villi or "finger-like" mucosal projections (*). The adjacent mucosa contains normal glands.

  5. Describe the histologic changes on this lower power image

  6. A section of the colon reveals a broad based polyp which for the most part forms villi (>50%)

  7. Describe the histologic changes

  8. Villi are lined by an epithelium which is dysplastic, with cells containing enlarged, hyperchromatic and pseudostratified epithelium

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