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Cereal Science and Technology in Today’s Academic and Industrial Environments: Case of the KU Leuven Laboratory of Foo PowerPoint Presentation
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Cereal Science and Technology in Today’s Academic and Industrial Environments: Case of the KU Leuven Laboratory of Food Chemistry. Professor Jan A. Delcour and colleagues, K.U.Leuven, B-3001 Leuven, Belgium. Overview. Importance of the Cereal Sector The Laboratory of Food Chemistry

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slide1

Cereal Science and Technology in Today’s Academic and Industrial Environments:

Case of the KU Leuven Laboratory of Food Chemistry

Professor Jan A. Delcour and colleagues,

K.U.Leuven, B-3001 Leuven, Belgium

overview
Overview
  • Importance of the Cereal Sector
  • The Laboratory of Food Chemistry
  • Patenting Contributes to the Mission
importance of the cereal sector
Importance of the Cereal Sector
  • Cereals for feed and food
  • Wheat, rice, barley, oats, rye
  • Bread, pasta, beer, biscuits, cakes
  • Wheat processing (sugar syrups)
major industrial players partners
Major Industrial Players/Partners
  • Recent Past

Puratos

  • Current

Amylum Cargill Cerealia

Danisco-Cultor Master Foods

Procter & Gamble Meneba

Remy Sedamyl Vamix

mission lab of food chemistry
Mission Lab of Food Chemistry

To fulfill a role in society by

  • 1/ generating and communicating basic insightsinto the starch, nonstarch polysaccharide, and storage and physiologically active protein constituents of cereals
  • 2/ applying and valorizing such insightswith the aim to understand and improve processing and/or final product quality in biotechnological processes where cereals are used
funding sources and staff
Funding Sources and Staff
  • 1/ Public funds: staff: 20 Basic component

- Backbone: University : 5 positions - Competitive research positions: University: 4; National/regional agencies: 9; EU: 2

  • 2/ Industry funds: staff: 20 Applied/valorization component
major fund sources 2001
Major Fund Sources 2001
  • Government, EU and University
  • KUL staff: 5
  • Competitive research positions: 15
  • Bench fees: ca EURO 270,000
  • Industry
  • Positions: 21 bench fees: ca EURO 330,000
  • Total budget ca EURO 2,350,000
laboratory of food chemistry
Laboratory of Food Chemistry
  • Permanent Staff

Dr J Delcour

  • TemporaryPost doctoral Staff

Dr C Courtin Dr W Debyser Dr A-M Loosveld Dr W Veraverbeke

  • Research Assistants - PhD Students

ir K Brijs ir F Delvaux ir G Depaepe ir V Derycke lic K Fierens ir S Frederix ir K Gebruers ir G Geldersir H Goesaert ir W Gys ir J Ingelbrecht ir C Maes ir K Moers ir I Trogh ir G Vandeputte ir I Verbruggen ir R Vermeylen

  • Administrative and Technical Staff

K Bosmans C Jordens K Mélotte H Van Den BroeckB Vangeneugden L Van Den Ende

microbial malting technology
Microbial Malting Technology
  • Permanent Staff

Dr J Delcour Dr C Michiels

  • Project Leaders

ir I Noots (ing R. Delrue)

  • Research Assistants

ing K De Bie ir C Garcia ir T Verwimp lic M Vandeynse

lic I Vanderhoeven ir S Vynck

  • Administrative and Technical Staff

K Cornelis S Fondeck C Jordens L Schuyten

laboratory facilities expertise
Laboratory Facilities & Expertise
  • Laboratory Facilities
  • * Micro Malting Units (1 - 10 kg) * Milling Units (1-25 kg)
  • * Bread Making Unit (10 - 100 g) * Extruder (1- 5 kg)
  • * Differential Scanning Calorimeters * Rapid Visco Analyzer
  • * Brabender (High Pressure) Viscographs * Bruker NMR
  • * Kofler Hot Stage * Brabender Farinograph
  • * Stable Microsystems TA-TX2 * Mixograph
  • * Phast systems * FPLC/Akta Systems
  • * HPLC System * HPAEC System
  • * Gas Chromatography Systems
laboratory facilities expertise12
Laboratory Facilities & Expertise
  • Expertise
  • * Protein Isolation and Purification
  • * 1-D Gel Electrophoresis and iso-Electric Focussing of Proteins
  • * Dough Rheology
  • * Physico-chemical Properties of Starch
  • * Viscosimetry
  • * Nonstarch Polysaccharide Structures and Composition
  • * Cereal Processing
  • * Chemical Analysis of Foods
  • * Patenting
challenge
Challenge

To create an environment where

  • both the basic and applied component are well developped
  • an efficient transfer of technology is brought into practice
  • a good team spirit is present
slide14

Classic Technology Transfer Cycle

Research project

Public funding

Private funding

Published results

Unpublished results

University benefit

Industry benefit

slide15

Win-Win Transfer Cycle

Research project

Public funding

Incentives

Intellectual property

Private funding

Published results

Royalty streams

Win - win: joint university - industry benefit

experience with patents
Experience with Patents...
  • J.A. Delcour, R.C. Hoseney, Rye Extract Breadmaking Additives …., US 5,658,606.
  • G. Cleemput, J.A. Delcour, M. Hessing, Wheat NSP Hydrolysing Enzymes, WO 9709423.
  • T. Coppens, J.A. Delcour, D. Iserentant, Process for the Production of Malt, EP 0918844, WO 9849278.
  • W. Debyser, J.A. Delcour, Inhibitors of Xylanolytic and Glucanolytic Enzymes, WO 9849278, EP 0996709.
the taxi case
The TAXI Case…
  • Triticum aestivumXylanase Inhibitors

- Introduction

- Initial evidence, further work

- Conclusions

- Patenting and literature

- Negotiation of transfer

slide18

TAXI: Arabinoxylan structure

  • non starch cereal cell wall polysaccharides
  • hydrolysed by endoxylanases
  • D-xylopyranosyl residues
  • L-arabinofuranosyl residues
  • Ferulic acid residues
taxi initial evidence
TAXI: Initial Evidence

1. Arabinoxylan solubilisation during brewing

  • Pilsner type beers (100% barley malt)
  • Belgian wheat beers (60% barley malt, 40% unmalted wheat)

2. Inhibition of barley malt xylanolytic enzymes by wheat extracts

taxi further work
TAXI: Further Work

1. Protein purification and characterisation

2. Determination of inhibition patterns

taxi conclusions
TAXI: Conclusions
  • TAXI :
    • molecular weight 40,000
    • pI 8.8
    • two molecular forms
    • does not inhibit all endoxylanases
    • impact on breadmaking
slide22

A B C D

A. Control (50.2 1.5 cc)

B. Control + TAXI (46.3 1.0 cc)

C. Control + A. niger Xylanase (60.0 1.7 cc)

D. Control + TAXI + A. niger Xylanase (50.8 1.2 cc)

taxi conclusions23
TAXI: Conclusions
  • Importance in cereal processing
    • malting & brewing
    • breadmaking
  • Function ?
    • Endogenous endoxylanases
      • germination
    • Exogenous endoxylanases
      • plant defence
taxi patenting and literature
TAXI: Patenting and Literature

Debyser, W., Delcour, J.A., WO98/49278, filed 1997:

concept and structure of xylanase inhibitors (TAXI type)

Hessing, M., Happe, R.P., EP 0979830, filed 1998: structure of a non-TAXI endo-xylanase inhibitor

Debyser, W., Delcour, J.A., WO98/49278, filed 1997, published 1998

Sibbesen, O., Soerensen, J.F., WO00/39289, filed 1998: structure of TAXI inhibitor

Hessing, M., Happe, R.P., EP 0979830, filed 1998, published 2000

taxi patents
TAXI: Patents

- Debyser, W., Delcour, J.A., Gebruers, K., Goesaert, H., European patent, filed 2000 : structure of TAXI and HVXI inhibitors

- Sibbesen, O., Soerensen, J.F., WO00/39289, filed 1998, published 2000

to patent or not to patent
To patent or not to patent…
  • Difficulties encountered in patenting
    • Different language
    • Expensive
    • Time consuming effort
    • Not sufficiently appreciated internally
to patent or not to patent27
To patent or not to patent…
  • Negotiation of transfer
    • Difficult to find partners
    • Tough negotiations
    • Difficult to correctly estimate the value (lump sum, research funds, royalty rates)
to patent or not to patent28
To patent or not to patent…
  • The bright side…
    • Rewarding intellectually
    • Way to increase research funds
    • Brings a research group into the picture as an interesting partner for collaboration
    • Allows to move towards win-win cycles of transfer of technology