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Idiopathic pulm fibrosis (IPF) chronic interstitual lung dz -- honeycombed alveolar spaces alternating fibrosis and dila PowerPoint Presentation
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Idiopathic pulm fibrosis (IPF) chronic interstitual lung dz -- honeycombed alveolar spaces alternating fibrosis and dilation Sx: resp difficulty, hypoxemia, cyanosis, cor pulmonale . IPF -- diffuse interstitual fibrosis What is the FEV1/FVC ratio? Normal b/c both are reduced.

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Idiopathic pulm fibrosis (IPF) chronic interstitual lung dz -- honeycombed alveolar spaces alternating fibrosis and dilation

Sx: resp difficulty, hypoxemia, cyanosis, cor pulmonale

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IPF --

diffuse interstitual fibrosis

What is the FEV1/FVC ratio?

Normal b/c both are reduced

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IPF -- persistent injury leads to fibroblast proliferation and fibrosis

Which cells participate?

Lymphs, macros, type II pneumocytes

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IPF on CXR

radiodense linear streaking in lower lung fields

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Sarcoidosis

bilateral hilar lymphadenopathy (potato nodes)

systemic dz of non-caseating granulomas

Immune involvement:

cell-mediated rxn to unknown antigen -- anergy to common skin test antigens

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Intraaveolar hemorrhage -- hemosiderin macros

What syndromes are associated with this?

Goodpasture’s, Idiopathic Pulm Hemosiderosis, Vasculitis-Associated Hemorrhage

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Silicosis

thickened pleura upper lobe, white is collagen

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Silicosis

concentric collagen bands in nodules

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Asbestos -- diffuse interstitual fibrosis

Clinical course

progressive dyspnea, cough, sputum, CHF, cor pulmonale

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prominent interstitial markings in bases, pleural thickening at the costophrenic angles and lower lateral chest walls, and a calcified pleural plaque in the left hemidiaphragm

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large right pleural effusion and more extensive pleural thickening -- mesothelioma on resection

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Pulmonary infarct -- hemorrhagic, uncommon due to dual blood supply -- the more peripheral the embolus, the greater the chance for infarction