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Role of Mannose-6-Phosphate Receptors in Cellular Processes: Insights from Acidic Micro-environment Activation

This study delves into the impact of Mannose-6-Phosphate (Man-6-P) receptors on cellular mechanisms, focusing on their function at acidic pH levels. Analysis reveals associations with endocytosis, degradation, apoptosis, and transcription, shedding light on the intricate cellular pathways involved. The role of Man-6-P receptors alongside other proteins in endosomes, lysosomes, Golgi, and the ER is explored, emphasizing their influence in cellular homeostasis and fate. Findings suggest a pivotal role in regulating crucial processes within the intracellular environment.

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Role of Mannose-6-Phosphate Receptors in Cellular Processes: Insights from Acidic Micro-environment Activation

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  1. Man 6P receptors Man6P Man6P Asn70 Asn199 pro 4 K NH2 COOH 14 K 34 K Asp Asp 1 -44 348 33 231 catalytic site Figure 1

  2. Tumor micro-environment Activation at acidic pH Secretion Endocytosis 52K 52K 52K 52K 48K M6P receptors and other proteins Endosomes Lysosomes Degradation Golgi Apoptosis ER 34K 34K 14K 14K Cytosolic cath-D Transcription ? Nucleus Figure 2

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