liver transplantation a bond regenerated between brothers
Skip this Video
Download Presentation
Updated PSC project

Loading in 2 Seconds...

play fullscreen
1 / 20

Updated PSC project - PowerPoint PPT Presentation

  • Uploaded on


I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about 'Updated PSC project' - jmcguire215

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
liver transplantation a bond regenerated between brothers

Liver Transplantation: A Bond Regenerated Between Brothers

Jessica McGuire

Professor Cohen

Anatomy and Physiology

16 February 2011

Johnson & Wales University

donating life
Donating Life
  • James McGuire’s Insurance Application required the routine battery of blood tests
  • There were problems with James’ liver numbers
  • The application was declined and he was immediately directed to go see a Doctor.
Perfectly Healthy Before
  • By October James’ health had declined at a rapid rate and he was admitted to the hospital
  • His Doctor concluded that he in fact had Primary Schlerosing Cholangitis
primary schlerosing cholangitis
Primary Schlerosing Cholangitis
  • Primary Schlerosing Cholangitis (PSC) is a rare liver disease that typically affects Men in their 30-40s
  • Doctors still don’t know what causes it.
  • Average time between diagnosis and transplant: 9-10 years
four years
Four Years
  • In four years James had gone from feeling perfectly normal to having his name added to the cadaver waiting list.
  • Over four years he had become very tired and fatigued
  • During that time his skin turned ‘yellow’ or “jaundiced” because his liver couldn’t get the bile out of his system.
Organs used for transplant typically come from cadavers
  • More than 96,000 people nationwide are waiting for an organ transplant
  • More than 1,400 are in Arizona
  • Every 12 minutes a name is added to the national transplant waiting list
  • An average of 18 people die each day waiting for an organ.(UNOS)
a second option
A Second Option
  • The liver is one of the few organs that can be transplanted from a living donor
  • The liver is made up of two parts, a right lobe and a left lobe
  • The right lobe is removed from the donor and transplanted into the recipient
  • The donor’s remaining left lobe regenerates itself in about 6 weeks
testing process
Testing Process
  • The family decided that a living donor would give James the best chance of survival, and a normal life.
  • The following criteria must be met: Blood type, Cross match, Antibody screen, Urine Tests, X-Rays, Arteriogram, Psychiatric and Psychological Exams (wives are tested as well) (Mayo Clinic).
  • Final Blood Test and Cross Match (done within 48 hours of the surgery)
  • A friend volunteered and was eliminated due to vessel anatomy
  • Kelly (Sister) was eliminated due to lack of support system, and liver composition
  • Pernell was tested March, 2006 and was found to be a suitable match


just do it
“Just do it”
  • April 17, 2007 Transplant day
  • Pernell went into surgery first, it took the Doctors five hours to remove the right lobe of the liver.
  • The liver is dissected at the Falciform Ligament
  • The surgery takes about 10-12 hours
  • The liver should be pink and fleshy, James’ liver was completely green from the bile and rock hard due to the scarring.
  • Due to the severity of James’ liver damage his entire liver was removed and replaced with part of Pernell’s
Right Lobe

Right Lobe



Left Lobe

Diseased PSC Liver

Healthy Liver

  • Although Pernell had undergone the battery of testing, once he was open on the table it was discovered he had extra bile ducts.
  • One week post surgery, he thought that he was feeling sick due to the intensity of the operation, but bile was leaking into his abdomen
  • Dr. Mulligan’s first complication in 55 living donor transplant’s
  • Common complication in recipient, but not the donor
  • Stents were inserted and replaced four different times for drainage and his condition stabilized
post transplant
Post – Transplant
  • James’ long term prognosis is good
  • The success rate for a single organ transplant is 80%(UNOS)
  • The biggest obstacle is organ rejection, which James will continue to take medication to prevent
  • As long as he stays healthy this should not affect his typical lifespan.
James McGuire

Pernell McGuire

five years post transplant
Five Years Post-Transplant
  • Pernell is currently the managing partner of McGuire Gardner PLLC. A law firm in Arizona
  • James is currently an Attorney for the firm helping to manage the Tempe, AZ office.
  • Both are wakeboarding enthusiasts, and can typically be found on a boat with their families