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Cytokine production of human preimplantation embryos

Cytokine production of human preimplantation embryos. M. H. Özörnek, P. Bielfeld, U. Koldovsky Dept. OB&GYN, Heinrich Heine University, Düsseldorf, Germany. IFN gamma and IL-10 levels on day 1 vs. day 2. IFN gamma levels before implantation. day 2. day 3. day 4. day 5.

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Cytokine production of human preimplantation embryos

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  1. Cytokine production of human preimplantation embryos M. H. Özörnek, P. Bielfeld, U. Koldovsky Dept. OB&GYN, Heinrich Heine University, Düsseldorf, Germany

  2. IFN gamma and IL-10 levels on day 1 vs. day 2

  3. IFN gamma levels before implantation day 2 day 3 day 4 day 5

  4. Human embryo do not produce CSF-1 and LIF, at least 2-5 days after fertilisation.

  5. EGF production of human embryo

  6. Importants of critical selection of recurrent pregnancy loss patients for successful immunotherapy M. H. Özörnek, B. Mikat-Drodzdynski, U. Koldovsky Dept. OB&GYN, Heinrich Heine University, Düsseldorf, Germany

  7. Conditions for ImmunotherapyUniversity of Düsseldorf • Primary recurrent pregnancy loss • Absence of "classical" abortion reasons • Absence of an autoimmune pathology • negativ APCA and EAI tests • negativ infection parameters (HIV,HBs-Ag,Anti HCV,TPHA,CMV)

  8. Immunodiagnostik • Antipaternal Cytotoxic Antibody (APCA) [cross-match] A test for prooving the presence of cytotoxic antibodies in patient serum against partner lymphocytes • Erythrocyt Antibody Rosette Inhibition (EAI) Test A test for prooving the Fc receptor blocking antibodies

  9. Protocol of Immunotherapy

  10. Immunotherapy results

  11. Conclusion • If RPL is primary, • If all losses are in 1. Trimester, • If there are no autoimmune antibodies, • If both EAI and APCA tests are negativ Immunization is a realistic therapy!

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