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LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES

LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES. MECHANISM OF BLOOD FLOW CONTROLL I.ACUTE CONTROLL OF LOCAL BLOOD FLOW A.VASODILATOR THEORY B.OXYGEN LACK THEORY. METABOLIC MECHANISM. A..REACTIVE HYPEREMIA B.ACTIVE HYPEREMIA.

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LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES

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  1. LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES • MECHANISM OF BLOOD FLOW CONTROLL • I.ACUTE CONTROLL OF LOCAL BLOOD FLOW • A.VASODILATOR THEORY • B.OXYGEN LACK THEORY

  2. METABOLIC MECHANISM • A..REACTIVE HYPEREMIA • B.ACTIVE HYPEREMIA

  3. AUTOREGULATION OF BLOOD FLOW DURING CHANGES IN ARTERIAL PRESSURE 1.METABOLIC MECHANIS M 2.MYOGENIC MECHANISM

  4. Special mechanism for acute blood flow control in specific tissues 1. Kidney : tubuloglomerular feedback mechanism > macula densa located at the jaxtaglomerular apparatus in the kidney. 2. Brain : Increase of CO2 and H ions. 3. Skin : Body temperature .

  5. NO • ROLE OF EDRF (NITIC OXIDE) IN LOCAL CONTROLL OF BLOOD FLOW

  6. LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES • 2.LONG TERM BLOOD FLOW REGULATION • A.CHANGE OF TISSUE VASCULARITY • B.ANGIOGENESIS • C.DEVELOPMENT OF COLLATERAL CIRCULATION

  7. Vascular remodeling in response to chronic changes in blood flow or blood pressure LAPLACE LAW T= r X P T Vascular wall tension r radius P pressure

  8. HUMORAL CONTROL OF CIRCULATION • 1.VASOCONSTRICTOR AGENTS • A.NOREPINEPHRINE AND EPINEPHRINE • B.ANGIOTENSIN II • C.VASOPRESSIN • C.ENDOTHELIN • D.CALCIUM • E.INDIRECT EFFECT OF CO2

  9. HUMORAL CONTROL OF CIRCULATION • 2.VASODILATOR AGENTS • A.BRADYKININ • B.HISTAMINE • C.POTASSIUM,MAGNESIUM ,HYDROGEN AND CO2

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