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???? ??????. 2012/6/17. pharmaceutics. 4. ??????????????????????????,????????????????????????????????????????????(patch),?????????????????? . 2012/6/17. pharmaceutics. 5. ??TDDS ??????. ?1974?????????Transderm-Scop????????1981???????????????,??????????????????????????????????????. 2012/6/17. pharma
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1. ???? ?????? ????:???
???????????
2.
3. 2012/6/18 pharmaceutics 3 ??? ?? ??????????????(transdermal drug delivery systems, TDDS;Transdermel therapeatic systems, TTS)???????????????????????,?????????????????????????????,??????????????????????
4. 2012/6/18 pharmaceutics 4 ??????????????????????????,????????????????????????????????????
????????(patch),??????????????????
5. 2012/6/18 pharmaceutics 5 ??TDDS ?????? ?1974?????????Transderm-Scop????????1981???????????????,??????????????????????????????????????
6. 2012/6/18 pharmaceutics 6 ??
??????????????????????
????????????????,??????????
????????,??????
??????????????,??????,?????????,?????????
7. 2012/6/18 pharmaceutics 7 TDDS ???? ????????????,?????????,????????????????????
??????????????????,????????????????????
?????????????????,??????????????,?????????
8. 2012/6/18 pharmaceutics 8 ???????????????? (?)?????????
?????????????,????????????????????????????????(epidermis)?
9. 2012/6/18 pharmaceutics 9 (?)????????? ????????????,???????,??????,??????????????
???????????????????
10. 2012/6/18 pharmaceutics 10 ??????????? (?)????
????TDDS(membrane-moderated type TDDS)?????????????????????????????????
???????????????????,??????????????????
11. 2012/6/18 pharmaceutics 11 (?)????? ?????TDDS(adhesive dispersion type TDDS)????????????????
??????????????????,?????????????
12. 2012/6/18 pharmaceutics 12 (?)????? ????????????????????????,????????????????????,????????????????????????TDDS(matrix-diffusion type TDDS) ,????????????
13. 2012/6/18 pharmaceutics 13 (?)???? ????TDDS(microreservoir type TDDS)??????????????????????????????????????(?PEG)?????,??????????????????,????????,???????????,??????????????????????????????????,????????????????,???????,???????
14. 2012/6/18 pharmaceutics 14 ??? ??????????? ?????????????
(?)????
???????;
??????;
?????;
?????????????
15. 2012/6/18 pharmaceutics 15 (?)????????? ?????????
TDDS????:
?????????????
?????????????
???????????????????????????
16. 2012/6/18 pharmaceutics 16 ????????
?????600??????????? ??????????????????????,?????,??????,??????;
pH?pKa
??????????????,????????????????????,????????????????
17. 2012/6/18 pharmaceutics 17 TDDS?????
??????????????????????,??????????????,TDDS???????????????????
???????
??????????????,????????????
???????????????????,????????????
18. 2012/6/18 pharmaceutics 18 ??TDDS??????????? ???????(penetration enhancers) ???????????????,????????????
?????????????????????????????????????????????????????????????????????
19. 2012/6/18 pharmaceutics 19 1?????? ?????????????????????????,?????????
????????????????,????,?????????,???????????(CMC)??,???????????????????
?????????????,???????????????????
20. 2012/6/18 pharmaceutics 20 2??????(DMSO) DMSO
??????:?????
?????????
??:?????????
??????(DCMS )
????,??????????????????
21. 2012/6/18 pharmaceutics 21 3??????? ?????????????????????
22. 2012/6/18 pharmaceutics 22 4?????? ??2~5?????????????????????,????????,??????????????????
23. 2012/6/18 pharmaceutics 23 5???????? ??? ,?????????????
????????
?????
24. 2012/6/18 pharmaceutics 24 ?????????????? ?????(striping of stratum corneum)
????????(hydration of stratum corneum)
?????(iontophoresis)
????(electroporesis)
????(phonophoresis)
?????(thermal energy)
??????,?????????(liquid injection)????????(powder injection)
25. 2012/6/18 pharmaceutics 25 ????????(synthesis of lipophilic analogs);
???????(delipidization);
??????????(coadministration of chemical permeation enhancer);
???????(synthesis of prodrugs)?
26. 2012/6/18 pharmaceutics 26 ?????(biochemical approach) ???????????(synthesis of bioconvertible prodrugs)
??????????(coadministration of methabolism inhibitor)
27. 2012/6/18 pharmaceutics 27 (?) ?????? (iontophoresis) ???????????????????????????????????????????????
28. 2012/6/18 pharmaceutics 28
29. 2012/6/18 pharmaceutics 29
30. 2012/6/18 pharmaceutics 30
31. 2012/6/18 pharmaceutics 31
32. 2012/6/18 pharmaceutics 32
33. 2012/6/18 pharmaceutics 33
34. 2012/6/18 pharmaceutics 34
35. 2012/6/18 pharmaceutics 35
36. 2012/6/18 pharmaceutics 36
37. 2012/6/18 pharmaceutics 37
38. 2012/6/18 pharmaceutics 38
39. 2012/6/18 pharmaceutics 39
40. 2012/6/18 pharmaceutics 40
41. 2012/6/18 pharmaceutics 41
42. 2012/6/18 pharmaceutics 42
43. 2012/6/18 pharmaceutics 43
44. 2012/6/18 pharmaceutics 44
45. 2012/6/18 pharmaceutics 45
46. 2012/6/18 pharmaceutics 46 ??? ????????? ????????????????
1????????
(1)???
(2)???
???
???
47. 2012/6/18 pharmaceutics 47
48. 2012/6/18 pharmaceutics 48 3????????? ?????
??
49. 2012/6/18 pharmaceutics 49
50. 2012/6/18 pharmaceutics 50
51. 2012/6/18 pharmaceutics 51
52. 2012/6/18 pharmaceutics 52
53. 2012/6/18 pharmaceutics 53
54. 2012/6/18 pharmaceutics 54
55. 2012/6/18 pharmaceutics 55
56. 2012/6/18 pharmaceutics 56
57. 2012/6/18 pharmaceutics 57
58. 2012/6/18 pharmaceutics 58
59. 2012/6/18 pharmaceutics 59
60. 2012/6/18 pharmaceutics 60
61. 2012/6/18 pharmaceutics 61
62. 2012/6/18 pharmaceutics 62
63. 2012/6/18 pharmaceutics 63
64. 2012/6/18 pharmaceutics 64
65. 2012/6/18 pharmaceutics 65
66. 2012/6/18 pharmaceutics 66
67. 2012/6/18 pharmaceutics 67 ??? ??????????????????????????????,?????????????????????
68. 2012/6/18 pharmaceutics 68 ??????????????,????????????????????????
69. 2012/6/18 pharmaceutics 69 ???????????????,???180°???????(?PSTC-1?(PSTC,pressure-sensitive tape council)???
s = S/LB×C
180°???????????????????,???????????????
70. 2012/6/18 pharmaceutics 70
71. 2012/6/18 pharmaceutics 71 (?) ??????????????
????????????F??????,???????????
?????=(AUCTDDS/DTDDS)/(AUCIV/DIV)
?????=????????????????
????????????