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Investigating p53-mediated Apoptosis Pathway in Mitochondria

This supplementary figure showcases the impact of p53 variants on apoptosis in mitochondria. Various proteins and markers are analyzed using western blotting. The study delves into the molecular mechanisms behind cell death regulation.

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Investigating p53-mediated Apoptosis Pathway in Mitochondria

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  1. Supplementary Figure 5 A B MITOCHONDRIA TOTAL WT S46A WT S46A p53 RITA – + + – WB: p53 % of apoptotic cells α-amanitin – + – + WB: VDAC WB: HIPK2 WB: PCNA WB: p53pS46 NT RITA WB: p53 WB: Actin C D pLPC Pin1-HA MITOCHONDRIA TOTAL – + RITA – + RITA – + – + WB: PARP-p85 WB: p53 WB: HA WB: PCNA WB: actin WB: VDAC F E

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