RNA Polymerase

RNA Polymerase

mRNA being formed from a strand of DNA by proteins

HUMAN ATGCTTCCGGGCACATT...ACGAG CHIMP ATGCTTCCGGGCACATT...ACGAG RAT ATA..TCGGAGTACATCGCAACGAA HUMAN C.TCAGTGCCTGCCGGAAATCTCCC CHIMP C.TCAGTATCTGCCGGAAATCTCCC RAT CATTGGTGCCTTTTGCATGTTTGCC HUMAN ACCTGGTGGCA...ACCTACCCTTG CHIMP ACCTGGTGGCA...ACCTACCCTTG RAT ACCCATTTTCATGAACTTACCGCTT Segment of DNA from Humans, Chimps and Rats Genetic differences from 80 million years of separation compared to about 5 million years

Senegal haplotype from the Atlantic Coast of West Africa Benin haplotype from Central West Africa, Angola, and Kenya Bantu haplotype from Zaire, the Central African Republic, Angola, and Kenya Asian haplotype from Eastern Province of Saudi Arabia, and Central India In the U.S., the disease occurs in 1 in every 500 African American births and 1 in every 1000-1400 Hispanic American births.

RNA Polymerase

RNA Polymerase

Presentation Transcript

Activities of RNA Polymerase

Regulatory effects on RNA polymerase

Polymerase

89 - RNA polymerase 1 Subunit C

E. coli RNA polymerase (redux)

Lecture 12 RNA polymerase as a molecular motor Transcriptional control

RNA polymerase II The central enzyme of gene expression

a. DNA ligase b. DNA polymerase c. RNA polymerase d. Restriction enzyme

PFA0505c DNA-directed RNA polymerase 2 subunit, putative

T7 RNA Polymerase in a High Magnetic Field

RNA polymerase, the enzyme that transcribes the genetic code

Molecular basis of rna -dependant rna polymerase II activity

Eukaryotic RNA polymerase 18S+ 30 proteins= 40S

Formation of RNA Polymerase II pre-initiation complex

Bacterial RNA Polymerase New Insights on a Fundamental Molecular Machine

E. coli RNA Polymerase

RNA Polymerase binding

ECOLI RNA POLYMERASE

Lecture 12 RNA polymerase as a molecular motor Transcriptional control

Formation of RNA Polymerase II pre-initiation complex

RNA polymerase II The central enzyme of gene expression