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Full Blood Count every week for 4 weeks and then every 8 weeks PowerPoint Presentation
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Full Blood Count every week for 4 weeks and then every 8 weeks

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Full Blood Count every week for 4 weeks and then every 8 weeks

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Full Blood Count every week for 4 weeks and then every 8 weeks

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  1. Full Blood Count every week for 4 weeks and then every 8 weeks Liver Function Tests (LFT) at week 4 and then every 8 weeks Alanine Transferase (ALT) If >275IU/L at any point stop azathioprine & exit trial Bilirubin Alkaline phosphtatase (ALP) If >630IU/L at any point stop azathioprine & exit trial • Full Blood Count • Contact investigator if: • Lymphocytes <0.5 X 109/L † If ALP ≥ 360 IU/L (ie ≥3x the upper limit of normal) repeat LFT in 2 weeks If bilirubin > 40mol/L Speak to investigator as patient must EXIT TRIAL # If ALT ≥ 120 IU/L (ie ≥3x the upper limit of normal) repeat LFT in 2 weeks DECREASED OR SAME Continue treatment at same dose Repeat LFT in 6 – 8 weeks INCREASED Reduce daily dosage of azathioprine by 50mg Repeat LFT in 2 weeks DECREASED OR SAME Continue treatment at same dose. Repeat LFT in 8 weeks INCREASED Reduce azathioprine daily dosage by 50mg Repeat LFT in 2 weeks If repeat ALP < 360 IU/L continue same dose If repeat ALP ≥ 360 IU/L go back to † If 2nd time discuss with unmasked investigator DECREASED OR SAME Continue treatment at reduced dose Repeat LFT in 8 weeks INCREASED Speak to investigator as patient must EXIT TRIAL If repeat ALT < 120 IU/L Continue same dose If repeat ALT ≥120 IU/L go back to # If 2nd time discuss with unmasked investigator DECREASED OR SAME Continue treatment at reduced dose Repeat LFT in 8 weeks INCREASED Speak to investigator as patient must EXIT TRIAL