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GC-MSD Introducing the new 7890B/5977A. Badr Astiphan GCMS Product Sales Specialist 1-866-524-7936 302-290-5631 cell badr_astiphan@agilent.com. We are First in GC Continuously innovating. Units Installed >250,000 GC >60,000 MS. 7000 GC Triple Quad. 7200 GC QTOF. Low Thermal Mass

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GC-MSD Introducing the new 7890B/5977A


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slide1

GC-MSD

Introducing the new 7890B/5977A

BadrAstiphan

GCMS Product Sales Specialist

1-866-524-7936

302-290-5631 cell

badr_astiphan@agilent.com

Agilent Confidential

we are first in gc continuously innovating
We are First in GCContinuously innovating

Units Installed

>250,000 GC

>60,000 MS

7000 GC Triple Quad

7200 GC QTOF

Low Thermal Mass

Technology

Multi-Mode

Inlet

2010’s

Retention Time

Locking

2nd Gen Linear

Electron Capture

Detector

Electronic Pneumatic

Control

2000’s

6890 GC

1990’s

Hyperbolic

Gold Quad

Inert MS Ion Source

Capillary Flow

Technology

5970 MSD

Fused Silica

Capillary Column

1980’s

5890 GC

AutoInjection

1970’s

5840 GC

5880 GC

Microprocessor Control

Agilent Confidential

slide3

7890A/5975C GC/MSD:The Most Popular GC/MS in the World

The industry standard GCMS

Over 20,000

5975 systems since 2005

Agilent Confidential

agilent 5977 msd

Agilent 5977 MSD

Agilent Confidential

proven technologies improving the industry standards for gc sq
Proven TechnologiesImproving the Industry Standards for GC/SQ

Triple Axis Detector

Gold Quartz Quad

High Temperature Inert Source

Unique Entrance Lens Design

All of 5975’s features also built in 5977, such as “Gold Quad”, SIM/Scan, Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc..

Agilent Confidential

slide6

High Temperature Ion Source

Solid inert material – not a coating

  • Not damaged by multiple cleanings

Programmable to 350ºC

Improved response for many compounds

  • More robust operation for “dirty” samples
  • Better response for “sticky” compounds
  • Sharper peaks for high boilers (late eluters)

Polyaromatic Hydrocarbon (PAH)

  • … more performance for a wide range of applications

Agilent Confidential

slide7

Unique Entrance Lens Eliminates Pre-filter

New, improved lens

Agilent Confidential

slide8

Unique Entrance Lens Eliminates Pre-filter

Fringe fields

Agilent Confidential

slide9

Quartz – Gold – Hyperbolic and Beautiful!

Why quartz?

  • Low coefficient of linear expansion (expansivity; α)
    • dL = α L0dt [t = ºC; dL = change in length (m); L0 = length at 0 ºC]

Why gold?

  • Inert material with excellent electrical properties for high voltage

Why hyperbolic?

  • Ideal electrical field is generated by hyperbolic surfaces (NOT ROUND)

Much more than just a beautiful piece of glass

Round Quad

Agilent Confidential

slide10

Offset

Z

Y

X

Triple-Axis Detector

With a combination of three axes and appropriate shielding, noise from secondary particles can be reduced to a minimum

ion beam

Agilent Confidential

slide11

Triple Channel EM

Exit of the triple channels

Triple channels improve signal amplification

  • Lower initial EM voltage required

Triple channels increase life

  • Lower cost of operation

Collector removed to show exit passages

Collector

Agilent Confidential

expanded capabilities 7890b 5977a improving the industry standards for gc sq
Expanded Capabilities: 7890B/5977AImproving the Industry Standards for GC/SQ
  • Save Time & Energy
  • Sequence Scheduler
    • “Standby” post run
    • “Ready to run” from standby
    • “Bake Mode” as needed
    • Factory backflush option
    • Fast Vent capability
    • DS42i rough pump“standby” power reduction
  • Higher Ion Count
  • Extractor EI source
    • Increased ion count
    • S/N > 1500:1
    • IDL < 10 fg (industry first)
    • Improved thermal profile
  • Better Vacuum by Agilent Pump
  • New Agilent V304 Turbo
    • TwisTorr
    • Molecular Drag technology
    • Improved pumping light gases
        • H2 (220 L/s); He (255 L/s)
    • Agilent Floating Suspension
        • Longer life
        • Quiet operation
  • Faster Scanning
  • 20,000 u/s
    • But never equal to the 7200 Q-TOF speed or ‘scan’ sensitivity
  • Safety/Protection
  • Vacuum failure  Shut off gas (He or H2)
  • 7890B GC “Direct Communications Features
  • EMF, calculator, etc.

Agilent Confidential

new extractor ion source for 5977
New Extractor Ion Source for 5977
  • Why the Extractor EI Source?
  • Increase in ion count
    • True increase in sensitivity
  • Better trace level precision
    • Lower IDL and MDL

Proven sensitivity increase demonstrated with over 1500 7000 Series GC/TQ!

Agilent Confidential

comparison of inert and extractor ion source
Comparison of Inert and Extractor Ion Source

Repeller

(Push)

Ionization area

Drawout Plate

Ions

Extractor Lens

(Pull)

Ion Focus Lens

Entrance Lens

Mass Filter

More ions to Mass Filter

Inert Ion Source

Extractor Source

Agilent Confidential

extractor source etune sensitivity increase
Extractor Source “Etune” Sensitivity Increase

Blue – Extractor 40ppb solution (SVOC)

Red – Standard 40ppb solution (SVOC)

Agilent Confidential

more improvements on 5977 s extractor ion source improved thermal profile
More improvements on 5977’s Extractor Ion Source: Improved Thermal Profile

Why is this important?

Better performance of high boilers i.e. PAH even at lower concentration!

Good repeatability of PAH even at the trace level (5ppb)!!

10 Injections

80 min analysis

Improvement for better Mass Spectrometer of Gas Chromatograph

comparing repeatability of 80min method
Comparing repeatability of 80min Method

5975 result

Two years ago

5977 result

5977 result

200ppb PAH

5ppb PAH

Phthalates analysis with 5977 GC/MSD

key features of direct communication between 7890b and 5977a
Key features of “Direct Communication” between 7890B and 5977A

Safety Control

If 5977A MSD pump fail, 7890B will shut off the gas supply

Helium carrier gas : gas waste is eliminated

Hydrogen carrier gas: risk of explosion is reduced

Cool Down MSD Faster (FastVent)

When MSD Vent Cycle started, GC will cool down MSD analyzer at the optimum gas flow to MSD.

 40% faster when cooling down from 280C to 100C (< 25 min)

Agilent Confidential

  • Sleep/Wake mode
  • Sleep mode saves power (320W  190W)
  • Lower lab operating cost
saving energy and time

Saving Energy and Time

Power saved

Time saved using Fast Vent

Power( VA)

Source Temp

FastVent

Vent

Time(min)

Time saved

better hw features agilent turbo pump v304
Better HW Features: Agilent Turbo Pump (V304)
  • Innovation for:
  • Higher pumping performance
    • especially for He and H2
  • High reliability
    • lower cost of operation

Agilent Quality Standard

TwisTorr 304 FS

Press release : http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

Agilent Confidential

slide21

TwisTorr 304 FS: Vacuum Design

8 EDM turbo stages (rotor) designed to optimize pumping speed for light gases

8 Turbo stators made by pressed SST sheet technology

3 TwisTorr drag stages (spiral channels) designed for high compression ratio performances

Agilent’s new patent-pending Floating Suspension for robust, low noise operation

better hw features agilent rough pumps
Better HW Features: Agilent Rough Pumps

New IDP-3c

New DS42i

High performance

Energy saving design

“Inverter” not compatible with diff pump

High performance

Oil-free scroll pump

NH3 CI compatible

with Agilent Quality Standards

Agilent Confidential

agilent inert flow path from injection to detection
Agilent Inert Flow Path … From Injection to Detection

…now from a single supplier

Ultra Inert Inlet Liner

New

Ultimetal Inlet Weldment, Shell and Transfer Lines

Ultimetal – TCD, FPD, NPD/FID Jets

Ultra Inert Gold Seal

Ultimetal Capillary Flow Technology

Devices, Ultimate Union

Ultra Inert GC Column

Agilent Confidential

programmable helium conservation module
Programmable Helium Conservation Module
  • Works with Gas Saver function of 7890 based GC
  • Standby Method can be programmed after the sequence ends
  • Analytical methods are unchanged since Helium is still the carrier during the run
5977a gc msd idl specification
5977A GC/MSD IDL Specification

These are installation specification, performed on customer site, immediately after installation and carry a lot more value than a reference specs.

*Systems without an Autosampler will have only S/N specification.

IDL is a statistically derived value from the precision (%RSD) of 8 consecutive, splitless injections of 100fg OFN at 99 % confidence level. The more precise instruments (lower %RSD) will generate lower IDLs.

The Agilent 7890B/5977A with an ALS or CTC autosampler has the following specifications:

why idl specification is useful for the 5977 in sim
Why IDL specification is useful for the 5977 in SIM?
  • Influence of Noise in S/N specs
  • In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization
  • If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant
  • Value of IDL
  • IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance
  • IDL characterizes the whole system – AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions
the influence of the low noise on s n values same data file rms 5 second noise region
The Influence of the low Noise on S/N valuesSame Data File, RMS, 5 Second Noise Region

A 0.01 min. shift in the noise regionresulted a 6000 higher S/N value.

When the noise is insignificant (low), the derived S/N value is also insignificant!

Noise region: 5.65min - 5.73 min

S/N: 10785

Noise region: 5.66min - 5.74 min

S/N: 3335

S/N

S/N

Noise region: 5.65min-5.73 min

Noise region:

5.66min-5.74 min

market leading performance premium value the best just got better
Market Leading PerformancePremium Value: The Best Just Got Better

No one can now offer a better specification package than Agilent

Agilent Confidential

slide29

Market’s Best S/N (SNR) > 1500:1

  • Market’s Best Scan Rate = 20,000 u/s
  • Market’s ONLY IDL < 10 fg
  • Better science from Agilent
  • Statistical confirmation of entire system’s performance

Agilent Confidential

mass hunter gc msd software
Mass Hunter GC/MSD Software

MH

MassHunter Quant

CS

MassHunter Qual

MassHunter GC/MS Acquisition

And Use Either

MassHunter Data Analysis

OR

MSD ChemStation Data Analysis

MSD ChemStation DA

G1701FA

Agilent Confidential

msd chemstation da

MSD ChemStation

Standard interface

MSD ChemStation DA

Quantitation

Macros

QEdit

Reports

Library Searching

Agilent Confidential

masshunter workstation qualitative analysis
MassHunter WorkStation Qualitative Analysis

Chromatogram Results

Data Navigator

Method Explorer

Method Editor

Spectrum Results

Agilent Confidential

mass hunter quantitative analysis
Mass Hunter Quantitative Analysis

The QuantBatch screen looks like this.

  • Results Informationfor the batch can be displayed. Visual guides highlight specific data that fall outside specific, predefined conditions.

Results Information

  • Compound Information displays graphical representation of the peak, qualifier information, spectral information, and the ISTD. Visual guides help identify associated data problems.

Compound Information

Batch Information

(i.e., Calibration Curve)

  • Batch Informationprovides easy visualization and customization of relevant desired data.

Agilent Confidential

slide34

Unknowns Analysis

Agilent Confidential

masshunter excel reporting
MassHunter Excel Reporting

Agilent Confidential

  • Excel Based (Excel 2010 supported)
  • MassHunter application exports data in XML and graphics files
  • Templates define report formatting
  • Over 100 shipping report templates
  • Reports can be altered for desired information & appearance
  • Customization using Excel features (function, formatting, code)
  • Computer Based Training for report customization by users
  • Some customization available through Agilent
slide36

Application Notes

Agilent Confidential

flexibility performance and budget
Flexibility: Performance and Budget

Highest

GC Performance

& MS Performance

5977A EI

5977A EI/CI

7890B GC

Extractor source

DS42i

Balance of Price,

GC performance,

& MS performance

5977A Turbo MS

5977A Diff MS

7890B GC

Inert source

Lowest Price

Performance Meets

Method Requirement

5977E Turbo MS

5977E Diff MS

7820A

Stainless source

slide38

Maintenance and Support Issues

Agilent Confidential

slide39

Q&A Discussion

Agilent Confidential