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ANTIBODY AND ANTIGEN. Group 3 : M. Yusron Hasani ( 105090100111037 ) A. Muammar Kadafi (115090101111012 ) Nira Meirit a W. ( 115090100111017 ) Putri Indisari ( 1150901 0 7111 0 21 ). JURUSAN BIOLOGI FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNIVERSITAS BRAWIJAYA MALANG 2013.

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Antibody and antigen

ANTIBODY AND ANTIGEN

Group 3:

M. YusronHasani(105090100111037)

A. Muammar Kadafi (115090101111012)

NiraMeirita W.(115090100111017)

PutriIndisari(115090107111021)

JURUSAN BIOLOGI

FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM

UNIVERSITAS BRAWIJAYA

MALANG

2013


Antigen

ANTIGEN

Substance that stimulates the production of antibodies and can be recognised by a B cell receptor or antibody, or a T cell receptor.

Protein, polisakarida or other molecule

Part of the antigen which comes into contact with the antigen receptor is called the epitope or antigenic determinant


ANTIGEN STRUCTURE

Epitope, or antigenic determinant, is a small, specific portion of an antigen recognized by the immune system such as antibodies. A single antigen usually has several different epitopes. The region on an antibody which recognizes the epitope is called a paratope. Antibodies fit precisely and bind to specific epitopes.


Types of epitopes
Types of epitopes

  • linear or sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure

  • Conformational epitope that has a specific three-dimensional shape and its protein structure. In contrast, most antibodies recognize this epitope


What are the mhc molecules mhc
What are the MHC molecules? MHC:

  • Major histocompatibility Complex





Antigen antibody binding
Antigen-Antibody Binding

  • The binding between antibodies and antigens has high specificity and affinity resulting from various structural and energetic aspects.

  • Is a non covalent bond ( similar mechanism as lock and key on enzyme and a substrate )

  • Happens because the molecular structure of an antibody typical



Immune system on pre post natal
Immune system on pre-post natal

  • Pre-natal used IgG as antibody

  • Post-natal used IgA from colostrum as antibody



  • First exposure to antigen stimulate primary imun responses signalling by IgM few days after exposing.

  • Time between exposure and appearance of IgM antigen called the lag phase

  • In serum, IgG start to be detected 6-7 days after exposure


  • When second exposure to antigen occurs, secondary immune response in which IgM and IgG levels increased rapidly with a short lag phase

  • IgM levels did not exceed the peak levels of the primary response, but IgG levels rise much higher and lasts longer

  • Much better response faster on secondary immune response


s response in which


Thank you
Thank You response in which


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