Aspirin: From Tree Bark to Bayer – A Drug for the Ages. James Sur, M.D. History of Medicine The University of Chicago. How Much Do You Know?. What is the chemical name of Aspirin? Who is responsible for discovering Aspirin? What are the current medicinal uses of Aspirin?
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James Sur, M.D.
History of Medicine
The University of Chicago
460 BC - 377 BC
1980 – FDA approves use to reduce risk of stroke after TIA in men. (Stroke, 1977), (NEJM 1978)
1982 –Sir John Vane awarded nobel prize for his work.
1985 – FDA approves use of ASA to prevent MI in pts with previous MI (NEJM 1983) or UA history (NEJM 1985).
1996 – FDA proposes change of label to include its use in acute management of MI.
1997 – FDA broadens its recommendations in prevention of stroke to include women w/ TIA history, Men and women with minor stroke or MI history - and in lower doses (NEJM 1991) .
1998 – FDA officially endorses:
Reduces risk of death in AMI
Prevents recurrent CVA/TIA
Low Dose ASA reduces risk MI or CVAThe Story continues to unfold – Aspirin’s Second Career…