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PatientBase ™… .. (Decision Resources ’ Customizable Epidemiology Database). © Decision Resources, Inc., 2005. PatientBase ™ Features Methodology Demonstration Applications / Uses Appendix. PatientBase™. What is PatientBase™. Online database of 103 diseases and 153 indications

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patientbase decision resources customizable epidemiology database

PatientBase™…..(Decision Resources’ Customizable Epidemiology Database)

© Decision Resources, Inc., 2005

slide2

PatientBase™

    • Features
    • Methodology
  • Demonstration
  • Applications / Uses
  • Appendix
what is patientbase
What is PatientBase™
  • Online database of 103 diseases and 153 indications
  • Therapeutic Coverage
  • Geographic Focus
    • United States
    • Japan
    • France, Germany, Italy, Spain and United Kingdom
  • Frequency of Outputs
    • Released quarterly with most indications updated annually
  • Created, analyzed and validated by DR’s well-credentialed Epidemiology staff

1. Cancer 4. Immune & Inflammatory

2. Cardiovascular 5. Infectious

3. CNS 6. High Interest Diseases like Obesity,

Osteoporosis, Erectile Dysfunction etc.

patientbase features
PatientBase™ Features
  • 10 year forecast – 2004 to 2014
    • Prevalent cases / Incident cases
    • Diagnosed
    • Drug treated
    • Five-year age cohorts
    • By gender
    • Types of sub-population (Co-morbidity, Severity, Seasonality etc.)
    • Corresponding UN population
  • Data portability into Excel
  • Complete access to Sources & Methodology behind the data
patientbase development methodology
PatientBase™ Development Methodology
  • Epidemiologists conduct exhaustive secondary literature searches
    • Several hundred studies are reviewed for each indication
    • If appropriate, analyses of primary data sources are conducted
  • Epidemiologists choose the best country-specific population-based studies
    • Size and representativeness of subject population and rigor of case ascertainment methods
  • Academic epidemiological methods are applied in conducting analyses to determine methodology
  • Age- and gender-specific incidence or prevalence is applied to age- and gender-specific United Nations population estimates
    • For each country to reflect influence of demographic changes over time on patient populations
epidemiology data sources
Epidemiology Data Sources

DR’s expert epidemiologists consult primary data sources, team with expert reviewers, and review hundreds of secondary data sources for estimating incidence/prevalence trends

Bundes-Gesundheitssurvey 98

ECA

patientbase demonstration first page
PatientBase™ – Demonstration (First Page)

Begin by selecting

an indication (Up to 16 indications at one time)

Click to go to the Epi Query page

patientbase demonstration epi query step 2
PatientBase™ – Demonstration (Epi Query)Step 2
  • Subpopulation is the distribution of Prevalent/Incident cases specific to an Indication
    • provided for more than half of all diseases and conditions
      • Co-morbidity
      • Severity
      • Laboratory measure
      • Seasonality
      • Etiology
      • Pathogen type
      • Infection site
      • Treatment type
patientbase demonstration epi query step 3
PatientBase™ – Demonstration (Epi Query)Step 3
  • Prevalent cases: all patients with the disease/condition at a point in time
  • Incident cases: all patients newly diagnosed with the disease/condition
  • Drug-treated cases: all diagnosed patients who are receiving pharmacotherapy
  • Corresponding U.N. population data: the total number of United Nations-estimated people in the population that corresponds to the cases of people with the disease or condition
patientbase demonstration epi query step 4
PatientBase™ – Demonstration (Epi Query)Step 4
  • Regional total: total regional patient populations (United States, Europe, Japan)
  • Country total: total country patient populations (United States, France, Germany, Italy, Spain, the United Kingdom, and Japan)
  • Country and gender detail: breakout of country-specific patient populations by male and female
  • Country, gender, and age detail: breakout of country-specific patient populations by male and female and by 5-year age breakouts
patientbase demonstration epi query step 5
PatientBase™ – Demonstration (Epi Query)Step 5
  • Formatted table: data are presented in attractive table for ease of use and presentation
  • Raw data spreadsheet: data are presented in raw table which is easiest to manipulate when exported to Excel
  • Both formats can be exported to Excel for further manipulation
  • Forecast period: forecast is presented in 5 year increments
    • 2004 2009 2014
  • Client can choose to view annualized forecasts through 2014 or forecasts of individual years
patientbase demonstration epi results tool bar
PatientBase™ – Demonstration (Epi Results)Tool Bar
  • Methodology: thorough and transparent discussions of overall and country-specific methodologies used to obtain patient population estimates and subpopulations
  • Bibliography: complete bibliography of all sources analyzed for the methodology
  • Key Sources: country-specific list of primary sources used to estimate key patient populations and subpopulations
patientbase application uses
PatientBase™ – Application / Uses
  • Estimate the number of people with drug-treatable disease or condition over time
    • Percent diagnosed
    • Percent treated
  • Segment cases by age, gender, stage, severity, genetic factor, disease attribute, co-morbidity or country
  • Annualized population forecasts
  • Compare populations across Indications
support services
Support & Services
  • DR’s highly skilled Epidemiology staff will answer any questions regarding PatientBase™
    • Staff members with over 50 years combined work experience
  • DR’s Consulting Group along with Epidemiology staff can assist in any customized Epidemiology work
    • Additional Indications
    • Geography not covered in PatientBase™
oncology indications in patientbase for u s a japan europe france germany italy spain u k
Acute Myeloid Leukemia

Bladder Cancer-Superficial

Bladder Cancer-Metastatic

Bladder Cancer-Muscle-Invasive

Breast Cancer-Stage I

Breast Cancer-Stage II

Breast Cancer-Stage III

Breast Cancer-Stage IV

Cervical Cancer-Stage I

Cervical Cancer-Stage III

Cervical Cancer-Stage III

Cervical Cancer-Stage IV

Chronic Lymphocytic Leukemia-High Risk

Chronic Lymphocytic Leukemia-Intermed. Risk

Chronic Lymphocytic Leukemia-Low Risk

Chronic Myelogenous Leukemia

Colon Cancer-Stage I

Colon Cancer-Stage II

Colon Cancer-Stage III

Colon Cancer-Stage IV

Colorectal Cancer-Stage I

Colorectal Cancer-Stage II

Colorectal Cancer-Stage

Colorectal Cancer-Stage IV

Oncology Indications in PatientBase™- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

oncology indications in patientbase cont for u s a japan europe france germany italy spain u k
Esophageal Cancer - Distant

Esophageal Cancer - Limited

Esophageal Cancer - Regional

Esophageal Cancer - Unknown

Glioma

Liver Cancer - Distant

Liver Cancer - Limited

Liver Cancer - Regional

Liver Cancer - Unknown

Malignant Melanoma-Stage I

Malignant Melanoma-Stage II

Malignant Melanoma-Stage III

Malignant Melanoma-Stage IV

Multiple Myeloma-Stage I

Multiple Myeloma-Stage II

Multiple Myeloma-Stage III

Non-Hodgkin's Lymphoma-Aggressive

Non-Hodgkin's Lymphoma-Indolent

Non-Small-Cell Lung Cancer-Stage I

Non-Small-Cell Lung Cancer-Stage II

Non-Small-Cell Lung Cancer-Stage III

Non-Small-Cell Lung Cancer-Stage IV

Ovarian Cancer-Stage I

Ovarian Cancer-Stage II

Ovarian Cancer-Stage III

Ovarian Cancer-Stage IV

Oncology Indications in PatientBase™ Cont.- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

oncology indications in patientbase cont for u s a japan europe france germany italy spain u k1
Pancreatic Cancer-Distant

Pancreatic Cancer-Localized

Pancreatic Cancer-Regional

Prostate Cancer-Stage I

Prostate Cancer-Stage II

Prostate Cancer-Stage III

Prostate Cancer-Stage IV

Rectal Cancer-Stage I

Rectal Cancer-Stage II

Rectal Cancer-Stage III

Rectal Cancer-Stage IV

Renal Cell Carcinoma-Stage I/II

Renal Cell Carcinoma-Stage III

Renal Cell Carcinoma-Stage IV

Small-Cell Lung Cancer-Extensive

Small-Cell Lung Cancer-Limited

Stomach Cancer - Distant

Stomach Cancer - Limited

Stomach Cancer - Regional

Stomach Cancer - Unknown

Oncology Indications in PatientBase™ Cont.- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

slide23
Central Nervous System Indications in PatientBase™- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

  • Acute Ischemic Stroke
  • Alzheimer’s Disease
  • Attention-Deficit/Hyperactivity Disorder-Adult
  • Attention-Deficit/Hyperactivity Disorder-Pediatric
  • Bipolar Disorder
  • Chronic Low Back Pain
  • Dementia
  • Epilepsy
  • Generalized Anxiety Disorder
  • Insomnia
  • Major Depression
  • Migraine (Prophylaxis)
  • Mild Cognitive Impairment
  • Minor Depression
  • Multiple Sclerosis (Chronic-Progressive)
  • Multiple Sclerosis (Relapsing-Remitting)
  • Narcolepsy
  • Obsessive-Compulsive Disorder
  • Obstructive Sleep Apnea
  • Osteoarthritic Pain
  • Panic Disorder
  • Parkinson’s Disease
  • Post-operative Pain
  • Restless Legs Syndrome
  • Rheumatoid Arthritic Pain
  • Schizophrenia
  • Social Anxiety Disorder
  • Postherpetic Neuralgia
  • Painful Diabetic Neuropathy
  • HIV-Related Neuropathic Pain
slide24
Infectious Diseases Indications in PatientBase™- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

  • Acute Exacerbations of Chronic Bronchitis
  • Community-Acquired Pneumonia
  • Hepatitis B
  • Hepatitis C
  • Herpes Zoster
  • HIV-Newly Diagnosed Population
  • Human Immunodeficiency Virus
  • Influenza A and B
  • Methicillin-Resistant Staph A
  • Sepsis
  • Complications of Soft Skin Tissue Infection
cardiovascular indications in patientbase for u s a japan europe france germany italy spain u k
Cardiovascular Indications in PatientBase™- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

  • Acute Heart Failure
  • Acute Myocardial Infarction
  • Atrial Fibrillation
  • Chronic Heart Failure
  • Coronary Heart Disease
  • Dyslipidemia
  • Hypertension
  • Peripheral Arterial Disease
  • Post-Myocardial Infarction
  • Pulmonary Arterial Hypertension
  • Non-ST-Elevation Myocardial Infarction
  • Venous Thromboembolism
slide26
Immune and Inflammatory Disorders Indications in PatientBase™- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

  • Allergic Rhinitis
  • Asthma
  • Crohn’s Disease
  • Diabetic Nephropathy
  • Eczema/ Atopic Dermatitis
  • Metabolic Syndrome
  • Fibromyalgia
  • Osteoarthritis
  • Psoriasis
  • Rheumatoid Arthritis
  • Systemic Lupus Erythematosus
  • Type 1 Diabetes
  • Type 2 Diabetes
  • Ulcerative Colitis
  • Urticaria
high interest disease in patientbase for u s a japan europe france germany italy spain u k
High-Interest Disease in PatientBase™- For U.S.A, Japan & Europe (France, Germany, Italy, Spain, U.K.)

Appendix

  • Age-Related Macular Degeneration (Wet)
  • Benign Prostatic Hyperplasia
  • Chronic Obstructive Pulmonary Disease
  • Diabetic Neuropathy
  • Diabetic Retinopathy
  • Erectile Dysfunction
  • Female Sexual Dysfunction
  • Gastroesophageal Reflux Disease
  • Irritable Bowel Syndrome
  • Obesity
  • Osteoporosis
  • Urinary Incontinence (Urge)
  • Urinary Incontinence (Stress)
slide28

For Further Information

North America

Mr. Bob Fucile

Tel. 781-296-2500

Fax 781-296-2550

rfucile@dresources.com

Decision Resources, Inc.

260 Charles Street

Waltham, MA 02453

Europe

Ms. Vera Bisegna

Tel. +32-2-351-10-79

Fax +32-2-351-23-47

vbisegna@decisionresources.be

Decision Resources International, Inc.

Avenue des Chasseurs, 1

1410 Waterloo, Belgium

Japan

Ms. Makiko Yoshimoto

Tel. +81-3-5401-2615

Fax +81-3-5401-2617

makiko@dresources.jp

Decision Resources International, Inc.

Fukide Building F4

4-1-13 Toranomon

Minato-ku, Tokyo 105-0001 Japan