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Analysis of Conserved Regions and Predictions in TIM Sequences Related to P. falciparum

This study presents a comprehensive analysis of TIM (Transport Involved in Metabolism) sequences, focusing on conserved region repeats and predicted transmembrane helices. We utilize multiple sequence alignment and PSI-BLAST to identify regions homologous to known proteins and those unique to our dataset. Findings include a notable similarity to antigenic proteins of the Trophozoite stage of *Plasmodium falciparum*, along with locations of missing active site residues and conserved cysteine in dimer interfaces. This work enhances our understanding of TIM within the *P. falciparum* genome.

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Analysis of Conserved Regions and Predictions in TIM Sequences Related to P. falciparum

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  1. K 12 H 95 E 165 Multiple sequence alignment of TIM sequences Conserved region repeats after few residues

  2. Information on the annotated TIM

  3. Information on the annotated TIM

  4. Transmembrane region prediction output for the first 236 residues PSI-BLAST output for the first 236 residues

  5. Region showing similarity to the antigenic protein of the Trophozoite stage of P.falciparum 1 1 114 114 115 115 Predicted transmembrane Helix Predicted transmembrane Helix 133 133 134 134 236 236 Region showing no homology to any of the known proteins Region showing no homology to any of the known proteins 235 235 338 Region showing homology to known TIM Region showing homology to known TIM 338 337 337 476 476 Region with the missing active site glutamic acid Region with the missing active site glutamic acid Conserved Cys in the dimer interface Proposed model of the Annotated TIM in the P.falciparum genome

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