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Overview of the Immune System

Overview of the Immune System. A Historical perspective. First Historical reference. Thucydides, first refers to immunity describing a plaque in Athens (430 BC). Variolation. Crude attempts at immunization were made in the fifth century by the Chinese and the Turks. Edward Jenner (1798).

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Overview of the Immune System

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  1. Overview of the Immune System A Historical perspective

  2. First Historical reference Thucydides, first refers to immunity describing a plaque in Athens (430 BC)

  3. Variolation Crude attempts at immunization were made in the fifth century by the Chinese and the Turks

  4. Edward Jenner (1798)

  5. Louis Pasteur Proved that Vaccination works Used Dubious means to conduct his experiment Father of Microbiology Found vaccines for both Rabies and Anthrax a scourge of the nineteenth century

  6. Emil von Behring and Shibasaburo Kitsato (1890) provided the first insights into the mechaniism of immunity. They demonstrated that SERUM (THE NONCELLULAR PORTION OF BLOOD) could transfer the immune state to unimmunized host. This component could neutralize toxins, precipitate toxins, rupture (lyse) bacteria and agglutinate bacteria

  7. Antibody

  8. Phagocytes: White Blood Cells

  9. Cell Mediated Immunity Humoral and Cell mediated Immunity were both shown to be necessary for the immune response

  10. Paul Ehrlich (1900)

  11. Clone Wars?

  12. Anatomical Barriers: Skin Skin

  13. Mucous Membrane

  14. Sebum: Sebaceous Glands

  15. Cilia

  16. Lysozyme

  17. Interferon

  18. Endocytosis

  19. Phagocytosis

  20. Pinocytosis: Cell Mediated Endocytosis

  21. Endosomes:

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