Inflammation an overview. Hal Hawkins, Ph.D.,M.D. Basic Human Pathobiology Course, PATH 6266 May 7, 2012. Inflammation has been defined as the reaction to injury of vascularized tissue. ACUTE INFLAMMATION includes:. 1) Vasodilation and vascular leakage 2) Cellular:
Hal Hawkins, Ph.D.,M.D.
Basic Human Pathobiology Course, PATH 6266
May 7, 2012
1) Vasodilation and vascular leakage
EMIGRATION AND CHEMOTAXIS
The tongue of the frog provides an opportunity to see the microcirculation and the movements of neutrophils.
(from Marchesi and Florey)
Inositol triphosphate Ca++ release
Diacylglycerol Protein kinase C
e.g. Leukotriene B4
(reactive oxygen and nitrogen species)
Recognition of Pathogen Activated Molecular Pathways (PAMPs) including Toll Like Receptors, and Damage Activated Molecular Pathways (DAMPs) (together sometimes called Alarmins).
TLR’s stimulate release of multiple pro-inflammatory peptides.
DAMPs lead to assembly of inflammasomes, activation of caspase-1, and production of IL-1beta.