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Outcomes of Pancreas Transplants in the USA (1987-2010): Graft Function and Patient Survival

This study analyzes pancreas transplant outcomes in the USA from October 1987 to December 2010, focusing on primary deceased donor (DD) transplants. It includes data on graft function, patient survival rates, immunological graft loss, and early technical failures. A comparative analysis is presented for different transplant types including Simultaneous Pancreas-Kidney (SPK) and Pancreas After Kidney (PAK) transplants. The findings contribute valuable insights into the efficacy and long-term outcomes of pancreas transplants over more than two decades.

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Outcomes of Pancreas Transplants in the USA (1987-2010): Graft Function and Patient Survival

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  1. SPK Pancreas Graft Function USA Primary DD Pancreas Transplants, 10/1/1987 –12/31/2010 3/11

  2. SPK Pancreas Graft Function USA Primary DD Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  3. SPK Kidney Graft Function USA Primary DD Pancreas Transplants, 10/1/1987 –12/31/2010 3/11

  4. SPK Kidney Graft Function USA Primary DD Pancreas Transplants, 10/1/1987 –12/31/2010 3/11

  5. PAK Pancreas Graft Function USA Primary DD Pancreas Transplants, 10/1/1987 –12/31/2010 3/11

  6. Re-PAK Pancreas Graft Function USA Second DD Pancreas Transplants, 10/1/1987 –12/31/2010 3/11

  7. PAK Pancreas Graft Function USA Primary DD Pancreas Transplants, 1/1/1988 –12/31/2009 3/11

  8. PTA Pancreas Graft Function USA Primary DD Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  9. PTA Pancreas Graft Function USA DD Primary Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  10. Kidney Transplants after PTA USA Primary DD Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  11. ReTx Rate after Primary PAK USA Primary DD Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  12. ReTx Rate after Primary PTA USA Primary DD Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  13. ReTx Rate after Primary SPK USA Primary DD Pancreas Transplants, 10/1/1987 – 12/31/2010 3/11

  14. 1-Year Unadjusted Patient Survival USA Primary DD Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  15. 5-Year Unadjusted Patient Survival USA Primary DD Pancreas Transplants, 1 /1/1988 – 12/31/2009 3/10

  16. 10-Year UnadjustedPatient Survival USA DD Primary Pancreas Transplants, 1 /1/1988 – 12/31/2009 3/10

  17. 1-Year Pancreas/Kidney Graft Function USA Primary DD Pancreas Transplants, 10/1/1988 – 12/31/2010 2/11

  18. 5-Year Pancreas/Kidney Graft Function USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  19. 10-Year Pancreas/Kidney Graft Function USA Primary DD Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  20. Early Technical Pancreas Graft Failures USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  21. Early Technical Pancreas Graft Failures USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  22. 1 Year Immunological Pancreas Graft Failures USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  23. 1-Year Immunological Graft Loss USA DD Primary TS Pancreas Transplants, 1/1/1988 – 12/31/2010 3/11

  24. 5-Year Immunological Graft Loss USA DD Primary TS Pancreas Transplants, 1/1/1988 – 12/31/2009 3/10

  25. Early Technical Pancreas Graft Failures USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2009 SPK PAK PTA Transplant Year 3/10

  26. 1-Year Pancreas Graft Function USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010 SPK PAK PTA Transplant Year 3/11

  27. 1-Year Immunological Pancreas Graft Loss Rate USA DD Primary TS Pancreas Transplants, 1/1/1988 – 12/31/2009 SPK PTA PAK Transplant Year 3/10

  28. 5-Year Pancreas Graft Function USA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2009 PAK PTA SPK 2/09

  29. Patient Survival USA Primary DD Pancreas Transplants 1/1/2006 – 12/31/2010 Category n 1Yr Surv. PTA 43396.4% PAK 80096.0% SPK 4,12995.8% 3/11

  30. PAK Patient Survival by Kidney Donor Type USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2009 Kidney Dnr n 1Yr Surv. LD 672 97.2% DD 26495.8% p <0.01 3/10

  31. Major Causes of Patient Death USA Primary DD Pancreas Transplants 1/1/2005 – 12/31/2009 % SPK PAK PTA 0-3 3-12 > 12 0-3 3-12 > 12 0-3 3-12 > 12 Months Posttransplant 3/10

  32. Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2006 – 12/31/2010 DwFxPancreas censored Cat. n 1Yr Fxn SPK 4,122 88.4% PAK79882.6% PTA 43379.9% p < 0.0001 3/11

  33. SPK Pancreas Graft Fxn by Donor Type USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2009 Donor n 1Yr Surv. Non-Hrt-Dnr11689.0% Standard 4,030 84.9% p = 0.28 3/10

  34. Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2010 Cat. n 1Yr Fxn SPK 4,12285.5% PAK 79879.9% PTA 43377.8% p < 0.0001 3/11

  35. Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2009 Anti-T-Cell Therapy & TAC & MMF Cat. n 1Yr Fxn PAK 54481.3% PTA 27185.6% SPK 2,73786.3% 3/10

  36. Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2009 Anti-T-Cell Therapy & Sirolimus based Protocol Cat. n 1Yr Fxn PAK 9589.3% PTA 8790.2% SPK 40789.6% 3/10

  37. Major Causes of Px Graft Failure USA Primary DD Pancreas Transplants 1/1/2005 – 12/31/2009 % SPK PAK PTA 0-<3 3-<12 ≥ 12 0-<3 3-<12 ≥ 12 0-<3 3-<12 ≥12 Months Posttransplant 3/09

  38. Early Technical Failure Rate USA Primary DD Pancreas Transplants 1/1/2006 – 12/31/2010 * * P = 0.01

  39. Reasons for Early Technical Failures USA Primary DD Pancreas Transplants 1/1/2005 – 12/31/2009 3/10

  40. Early Technical Failures USA Primary DD ED Pancreas Transplants 1/1/2005 – 12/31/2009 3/10

  41. Immunological Pancreas Graft Loss USA Primary TS DD Pancreas Transplants 1/1/2005 – 12/31/2009 p = 0.0001 Category n 1Yr Loss PTA 413 6.0% PAK 811 5.5% SPK 3,687 2.1% 3/10

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