The Flu Pandemic of 1918. The “Spanish flu” pandemic that swept around the world from June 1918 to December 1919 killed between 50 and 100 million people (3-6% of the global population). 10-20% of those infected with the H1N1 influenza virus died compared to the normal flu fatality rate of 0.1%.
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Broad-spectrum antiviral agents are essential for defending against another severe flu strain while a vaccine is being developed.