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Antigen-presenting cell (APC) - PowerPoint PPT Presentation


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Gene silencing. Antigen-presenting cell (APC). ( 2) Phagosomal escape ・ Proton sponge effect of dendrimer ・ Disruption of phagosome membrane by a -CyD. (1) MR-mediated phagocytosis. ・ Enhancement of recognition ability by MR. Mannose receptor (MR). Phagosome. Lysosome.

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slide1

Gene silencing

Antigen-presenting cell (APC)

(2) Phagosomal escape

・Proton sponge effect of dendrimer

・Disruption of phagosome membrane by a-CyD

(1) MR-mediated phagocytosis

・Enhancement of recognition ability by MR

Mannose

receptor (MR)

Phagosome

Lysosome

Man-S-a-CDE(G3)/siRNA

complex

(3)Localization in cytoplasm

(4)Dissociation of siRNA

: Dendrimer (G3)

: a-CyD

: Mannose

: Spacer

: siRNA

: RISC

(5)Complexation

with RISC

Supplementary Figure 5. Proposed scheme for APC-selective RNAi efficiency of Man-S-a-CDE (G3, DSM4)/siRNA complex.