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This study investigates the impact of ERRγ and PGC1α on ATF6α expression levels using human cell models. Results show significant changes in ATF6α mRNA levels upon manipulation of ERRγ and PGC1α. Findings suggest a regulatory role for ERRγ and PGC1α in modulating ATF6α expression in human cells.
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ATF6α-N α-tubulin hATF6α-Luc D Supplemental Figure:3 Fold change - C ERRγ + + + - - PGC1α ** A B ** ** Human 2077gggaggtcaagc2066 Ad-GFP ** Relative ATF6α mRNA level Human 1612gataggtcacaa1601 Ad-shUS Ad-GFP Ad-shERRγ Ad-ERRγ Mouse 2433cccaggtcctct 2421 DMSO Tm * Ad-ERRγ Relative ATF6α mRNA level