slide1 n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Effects of Sonocrystallization on Crystal Size Distribution of Cloxacillin Benzathine Crystals PowerPoint Presentation
Download Presentation
Effects of Sonocrystallization on Crystal Size Distribution of Cloxacillin Benzathine Crystals

Loading in 2 Seconds...

play fullscreen
1 / 13

Effects of Sonocrystallization on Crystal Size Distribution of Cloxacillin Benzathine Crystals - PowerPoint PPT Presentation


  • 170 Views
  • Uploaded on

NERCICT. Effects of Sonocrystallization on Crystal Size Distribution of Cloxacillin Benzathine Crystals. Lecturer : Jieqiong Li Supervisor : Prof. Jingkang Wang Date : 2012.11.23. NERCICT. Introduction. Content. Experimental Sections. Results and Discussion. Conclusions.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Effects of Sonocrystallization on Crystal Size Distribution of Cloxacillin Benzathine Crystals' - gittel


Download Now An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

NERCICT

Effects of Sonocrystallization on Crystal Size Distribution of CloxacillinBenzathine Crystals

Lecturer:Jieqiong Li

Supervisor:Prof. Jingkang Wang

Date:2012.11.23

slide2

NERCICT

Introduction

Content

Experimental Sections

Results and Discussion

Conclusions

introduction
Introduction
  • Applications

NERCICT

introduction1
Introduction

NERCICT

proteins/peptides

sugars

Fig.1Effect of sonication on supersaturation.

introduction2
Introduction
  • Sonofragmentation of Needle Crystals

NERCICT

transient cavitation

buble collapse

buble growth

shockwave emerge

shockwave impact

seeding

introduction3
Introduction
  • reaction crystallization

NERCICT

Small Crystals

  • Final CSD

primary nucleation rate

  • ultrasound

crystal fragmentation rate

experimental sections
Experimental Sections

NERCICT

  • Different process conditions
  • Different lengths of insonated periods
  • Different seeding load
  • Different feeding rate

Conventional seeding

Seeding & ultrasonic interruption

Seeding in situ

Fig. 2 Schematic Diagram of The Experimental Setup: (A) jacketed reactor; (B) stirrer driver; (C) propeller; (D and E) peristaltic pump; (F and G) feed tanks; (H) thermostatic bath; (I) ultrasonic bath.

results discussion
Results & Discussion
  • Effect of Different Process Conditions

NERCICT

Fig.3 Optical photographs of cloxacillinbenzathine crystals just precipitate from the solution under different process conditions. (1) non-insonated experiment; (2) insonated experiment.

Fig. 4 Crystal size distribution (left) and optical photographs (right) of cloxacillinbenzathine under different process conditions. (A) non-insonated control experiment; (B) continuous insonation; (C) a short period of insonation interruption.(100×)

slide9

Results & Discussion

  • Effect of Different Lengths of Insonated Periods

NERCICT

  • Fig. 5 Optical photos of cloxacillinbenzathine with different lengths of insonation periods (200W): (A & a) seeding & without insonation; (B & b) seeding & insonated for 2min; (C & c) seeding & insonated for 4min.

Fig. 6 Effect of different lengths of insonation periods on the final crystal size distribution: (left) at ultrasound nominal power of 100W;(right) at ultrasound nominal power of 200W.

slide10

Results & Discussion

  • Effect of Different Seeding Load

NERCICT

Fig. 7 Effect of seeding load on the final crystal size distribution.

slide11

Results & Discussion

  • Effect of Different Feeding Rate

NERCICT

f

e

d

c

b

a

Fig. 8 Effect of feeding rate of the reaction material solutions on the cloxacillinbenzathine crystals : (left) the concentration of the solution when the crystals were detectable; (right) optical photographs of the crystals after precipitation from the solution under different feeding rate.

Fig. 9 Effect of feeding rate of the reaction material solutions on the final crystal size distribution.

conclusions
Conclusions
  • The longer the ultrasound performed and the more powerful the ultrasound was, the smaller the needle crystals were.
  • Crystals produced with low seeding loads present widespread and bimodal PSD, while the CSD was narrower and approaching to unimodal with increased seeding load.
  • Relatively slower feeding rate is favorable to produce products with improved properties.
  • Prolonged application of ultrasound after the nucleation onset has the potential to improve the final CSD and produce crystals with regular shape.

NERCICT

slide13

NERCICT

Thank You for Your Attention