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Digestants & Drugs Affecting Gallbladder. Promote the process of digestion in GI tract pancrealipase (Pancrease) - contains digestive enzymes Side effect: nausea, abd. cramps, & loose stools Take before or with meals ursodiol (Actigall) dissolves radiolucent noncalcified gallstones

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digestants drugs affecting gallbladder

Digestants & Drugs Affecting Gallbladder

Promote the process of digestion in GI tract

pancrealipase (Pancrease) - contains digestive enzymes

Side effect: nausea, abd. cramps, & loose stools

Take before or with meals

ursodiol (Actigall) dissolves radiolucent noncalcified gallstones

Side effect: N & V

antacids
Antacids
  • Drugs that buffer, neutralize or absorb hydrochloric acid in the stomach
  • Should be taken 1 hour after meals & @ bedtime
  • Watch for drug interactions
  • Magnesium (MOM) - diarrhea
  • Aluminum carbonate (Amphojel) - constipation
  • Maalox (aluminum hydroxide with & magnesium)
peptic ulcer treatment
Peptic Ulcer Treatment
  • Multi-drug treatment
  • Usually 2 antibiotics & a proton pump inhibitor or histamine blocking agent & then add bismuth subsalicylate - Pepto-Bismol
cytoprotective agents
Cytoprotective Agents
  • Sucralfate (Carafate) – tx duodenal ulcer
  • forms a protective, acid-resistant shield in the ulcer crater
  • give one hour before meals & at bedtime
  • Do Not Chew the Tablet
  • Administer antacids within 30 minutes before or after
  • Side effect: constipation
proton pump inhibitors
Proton Pump Inhibitors
  • Blocks the final step of acid production – decreases acid production
  • lansoprazole (Prevacid): side effect/diarrhea
  • omeprazole (Prilosec): side effect/diarrhea & headache
  • Swallow capsule whole & take before meals
  • Tx GERD, gastric ulcer, H. pylori
h 2 receptor antagonists
H2 Receptor Antagonists
  • Activation of H2 receptors increases gastric acid secretion so these drugs block this activation
  • cimetidine (Tagamet) – tx peptic & duodenal ulcer, GERD, hypersecretory conditions – generally well tolerated drug
  • ranitidine (Zantac)
  • famotidine (Pepcid)
  • nizatidine (Axid)
antiflatulents
Antiflatulents
  • Simethicone (Mylicon)
  • Defoaming agent- causes gas bubbles to unite
  • Relieves flatulence by dispensing and preventing the formation of mucus-surrounded gas pockets in the GI tract
gastrointestinal stimulant
Gastrointestinal Stimulant
  • Increases ACH – increases peristalsis – tx diabetic gastric stasis
  • antiemetic
  • Metoclopramide (Reglan)
  • AE – drowsiness & depression & Parkinson-like symptoms
  • When to give
antiemtics
Antiemtics
  • Prevent or relieve N & V, used with chemotherapy & postop
  • May exert effect on vomiting center, cerebral cortex, chemoreceptors trigger zone or vestibular apparatus
  • Side effect: headache, constipation & malaise
  • ondansetron hydrochloride (Zofran)
laxatives
Laxatives
  • Do not give with undiagnosed abdominal pain
  • Better to treat with increase fluids, vegetables, fruits & bran products
  • Laxative abuse
  • Saline (MOM)
  • Stimulant (Dulcolax, Ex-Lax)
  • Bulk Forming (Metamucil)
laxatives cont
Laxatives (cont.)
  • Lubricant (Mineral Oil)
  • Stool Softener (Colace)
  • Hyperosmotic (Lactulose & GoLYTELY)
antidiarrheal agents
Antidiarrheal Agents
  • Adsorbents: coats wall of GI tract, absorb bacteria or toxins causing the diarrhea & passing then out with stool (Kaopectate)
  • Pepto-Bismol - promotes absorption of fluids & has antimicrobial effect
  • diphenoxylate HCL with Atropine (Lomotil), “synthetic narcotic”, meperedine