What data should be collected on CONTROL SUBJECTS?. Katrina Gwinn-Hardy MD, NINDS. The NINDS Repository. Established 10-02 Samples and Clinical data on Parkinsons, Stroke, Epilepsy, ALS Over 3000 samples on affected, controls, families with accompanying data http://locus.umdnj.edu/ninds.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Katrina Gwinn-Hardy MD, NINDS
there’s no statements on criteria for controls in genetics studies per se! Many studies don’t describe any clinical features, just demographics…..
It doesn’t matter as long as you get a lot
Its so important…Controls need to be population
.. And also…age and gender matched…
use of spousal controls
Will lead to grievous errors
Spouses are great.. We insist on spousal controls….
“If you can’t tie good knots, tie a lot of them”
Age, Gender, Race
Type of control
Unaffected Spouse (indicate spouse diagnosis, ID)
Alz, ALS, Ataxia, Autism, Bipolar, Aneurysm, Cancer, Dementia, Depression, Diabetes, Dystonia, Epilepsy,,CAD, Memory Loss Migraine, MS, Muscle disease, PD, Schizophrenia, Suicide, Stroke
Any other samples from family
Who collected data
Neurologist, other MD, non-MD
Was the subject examined?
Results of neuro exam normal?