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Integrating Mouse and Human Gene Predictions for Enhanced Gene Recommendations

This study explores the synthesis of human and mouse gene predictions to enhance gene recommendations through combined search results. Key focus genes include MCM5, RPA2, CDK4, and HDAC1, with emphasis on their orthologs' significance in biological processes. By employing advanced calculations of paired hit P-values, the research aims to identify critical gene interactions that can inform genetic research. This integrative approach provides a valuable resource for researchers seeking insights into human genes of interest based on mouse data.

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Integrating Mouse and Human Gene Predictions for Enhanced Gene Recommendations

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  1. Human predictions found by combining mouse and human search results human predictions Human Query Genes unk(1) UBE2D3(2) *MCM5(28) … RPA2(13) ... CDK4 MCM5 MCM7 E2F1 PCNA HDAC1 … Human GENE RECOMMENDER human genes of interest *MCM5 RPA2 TIAL1 *MCM7 RBBP4 *HDAC1 *PCNA SSB SMAD DNMT1 … CDK4 MCM5 MCM7 E2F1 PCNA HDAC1 … Identify Mouse Orthologs Calculate P-value of Paired Hits Cdk4 Mcm5 Mcm7 E2f1 Pcna Hdac1 … *Mcm7(1) *Cdk4(2) *Mcm5(11) ... Rpa2(33) ... Mouse GENE RECOMMENDER Mouse Query Genes mouse predictions Mouse

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