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t-cells

Development of T-Cells<br>

ganeshgaonkar
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t-cells

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  1. T-Cells

  2. Development of T-Cells

  3. Thymic selection of T-Cells

  4. Types of T-Cells • CD4+ cells or TH-Cells TH0 , TH1 , TH2 • CD8+ cells or Cytotoxic T-Cells • Regulatory T-Cells

  5. Activation of T-Cell Signals: antigen, inter leukins,B7 protein co-stimulation Clonal expansion

  6. Functions of T-Cells • TH-Cells: activation of B-Cells, secretion of cytokines, delayed type hypersensitivity. • Cytotoxic T-Cells: kills cells infected with bacteria and virus, kills tumor cells and transplanted foreign cells during graft rejection. • Regulatory T-Cells: suppress immune response of T-Cells by regulating the population of T-Cells, prevent pathological self reactivity inhibiting auto immune diseases.

  7. Cytokines produced by T-Cells

  8. T-Cell mediated B-Cell activation Effector cells and memory cells

  9. Cell mediated immunity by CTL

  10. Interaction of T-Cells with antigen CD4+ T-Cells CD8+ T-Cells

  11. Variable region Constant region Immuno receptor tyrosine based activation motif

  12. T-cells and autoimmune diseases • Insulin dependent diabetes mellitus-pancreatic-β cells • Rheumatoid arthritis-connective tissue • Multiple sclerosis-white matter • Hashimoto’s disease-thyroid proteins and cells Immune disorders involving the thymus • Digeorge syndrome • Nezelof syndrome Immuno deficiency • AIDS

  13. Conclusion T-Cells play crucial role in recognition of processed antigen and it connects humoral immunity to cell mediated immunity

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