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HIV and T Cells - PowerPoint PPT Presentation


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HIV and T Cells. Luci Davidson Nabeel Parwez Peter Komar Chris Ostrander. Helper T cell Infected with HIV. The Helper T cell is shown in green, the virus is shown in red. HIV Life Cycle. Virus binds to CD4 protein on helper T cells Fuses with cell membrane

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hiv and t cells

HIV and T Cells

Luci Davidson

Nabeel Parwez

Peter Komar

Chris Ostrander

helper t cell infected with hiv
Helper T cell Infected with HIV

The Helper T cell is

shown in green, the

virus is shown in red.

hiv life cycle
HIV Life Cycle
  • Virus binds to CD4 protein on helper T cells
  • Fuses with cell membrane
  • Empties contents into cell
  • reverse transcriptase copies viral genetic material

from RNA into double-stranded DNA

  • integrase splices into cellular DNA
  • cell makes viral proteins and RNA using provirus
  • HIV protease cleaves new proteins
  • new proteins join RNA in new viral particles
  • particles bud from cell and infect others
types of t cells
Types of T Cells

HIV binds to CD4, but not CD8. Therefore, only Helper T cells

are affected.

course of infection
Course of Infection
  • rise of virus in blood which produces a drop in CD4

helper T cells

  • immune system recovers slightly, but HIV levels

remain steady for several years

  • when CD4 T cell level drops below 200 cells per

cubic mm blood, AIDS is diagnosed