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In Vivo Optical Imaging of Glucose Metabolism in Human Applications

This study explores the application of in vivo optical imaging, specifically utilizing 2-NBDG, a glucose fluorescence substitute, for investigating glucose metabolism in the human brain. Conducted by Vassiliy Tsytsarev and colleagues at the University of Maryland School of Medicine, the research highlights the potential of this imaging technique to track glucose utilization during brain activity, particularly in the context of epileptic seizures. The study also discusses the role of astrocytes and capillary glycogen in energy metabolism, providing insights into brain injury and rehabilitation.

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In Vivo Optical Imaging of Glucose Metabolism in Human Applications

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  1. In Vivo Optical Imaging: Human Application? Vassiliy Tsytsarev University of Maryland school of Medicine E-mail: tsytsarev@umaryland.edu

  2. Glucose Metabolism Capillary Glycogen TCA TCA Yongmei Chen and Raymond A Swanson Journal of Cerebral Blood Flow & Metabolism (2003) 23, 137–149; Astrocytes and Brain Injury

  3. Glucose Fluorescence Substitute: 2-NBDG 2-deoxy-d-glucose 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucopyranose (2-NBDG) D-glucose

  4. Glucose Fluorescence Substitute:In vivo imaging of epileptic activity using 2-NBDG

  5. Epileptic Seizures: Fluorescence Imaging

  6. fMRI vs NIRS

  7. Light Banana

  8. Light Banana: Oxygenation

  9. Main parts of experimental setup

  10. HITACHI: medical application

  11. Spectrum: T-ray

  12. EROS: Optical correlation of the EEG? Evoked Response Optical Signal (EROS) (Gratton et al, 2002, 6, 7)

  13. T-ray imaging

  14. Acknowledgments Drs. Shigeru Tanaka, Hidenao Fukuyama, Kazuyuki Imamura, Ayako Ajima, Hisayuki Ojima, Minoru Kimura and Jerom Ribot – Brain Science Institute of RIKEN and Kyoto University, Japan Dr. Sonya Bahar, Director, Center for Neurodynamics, University of Missouri at St. Louis Daisuke Takeshita and Douglas Joseph Brumm – Ph.D students, Center for Neurodynamics, University of Missouri at St. Louis Song Hu, Junjie Yao, Li Li – Ph.D. student of the Washington University in St. Louis Drs Konstantin Maslov and Lihong Wang – Department of Biomedical Engineering, Washington University in St. Louis

  15. Thank you very much for your attention

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