بسم الله الرحمن الرحيم. SODIUM BALANCE . OVERALL HANDLING OF NA +. Na + Reabsorption. Of total energy spent by kidneys, 80% is used for Na + transport Na + is not reabsorbed in the descending limb of the loop of Henle.
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descending limb of the loop of Henle
HCO3- ,Glucose and Amino acids.
In the late proximal tubule, Na+ is reabsorbed primarily with
Increase in GFR
Increase in filtration fraction
Increase in concentration of protein in peritubular capillaries
Increase in πc
Increase reabsorption in proximal tubule
Na+ reabsorption & K+ secretion
K+ reabsorption & H+ secretion
High K+ diet concentration inside thus principle cells increases electrochemical gradient across membrane
If substance is filtered , not reabsorbed or secreted , its plasma clearance rate equals GFR
0: normally albumin is not filtered across the membrane
0 :normally filtered glucose is completely reabsorbed back into the blood stream
is equal to the GFR.(Glomerular Marker) Inulin is a Fructose polymer ; freely filtered across the membrane and neither reabsorbed nor secreted.
PAH Clearance is use to Estimate ?
Renal Plasma Flow
~ 10 % PAH
ERPF = Clearance PAH
long loop of henle(Countercurrent multiplier) ,
vassarecta,( Countercurrent exchanger)
collecting ducts of all nephrones(osmotic equilibrating device) .
The descending limb
The ascending limb
It is impermeable to water. Therefore, water does not follow the salt by osmosis.
actively transports NaClout of the tubular lumen into the surrounding interstitial fluid.
Atonic Bladder Caused by Destruction of Sensory Nerve Fibers.