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Non-Lethal Chemical Agents Toxicity: Definitions and Calculations

Understand terms like IC50, LC50, LCT50, ICT50, and Safety Factor for CN and CS agents. Learn about lethal and incapacitating concentrations and dosage. Use the provided calculation information to estimate toxic levels accurately.

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Non-Lethal Chemical Agents Toxicity: Definitions and Calculations

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  1. NON-LETHAL CHEMICAL AGENTS TOXICITY of CN and CS

  2. DEFINITION OF TERMS

  3. m3 = Cubic meter (Approximately 35 cubic feet) • gm = Gram (0.353 oz.) • mg = Milligram (0.001 grams - to convert grams to milligrams multiply by 1,000) • cc = Cubic centimeter (0.000001 m3 or 1.0 gm) • 1 oz. = 28.350 gm • 66 minutes = time average man uses 1 m3 of air

  4. MEDIAN INCAPACITATION DOSAGE (IC50) - The amount of inhaled vapor or aerosol which is sufficient to incapacitate 50% of exposed personnel. Usually expressed in milligrams per minute in one cubic meter of air.

  5. INCAPACITATION CONCENTRATION TIME (ICT50) - • Concentration (IC50) multiplied by the time (t) of exposure that • incapacitates 50% of exposed personnel. Usually expressed in • minutes of exposure. • ! .004 mg/m3 - smallest amount a human can detect. • (British Government Study) • ! 0.5 mg/m3 - amount that riot bystanders usually retreat at. • (British Government Study) • ! 4.0 mg/m3 - amount that rioters will usually disperse at. • (British Government Study)

  6. Waco, Texas

  7. MEDIAN LETHAL DOSAGE (LC50) - The amount of inhaled vapor or aerosol which is sufficient to kill 50% of exposed personnel. Usually expressed in milligrams per minute in one cubic meter of air.

  8. LETHAL CONCENTRATION TIME (LCT50) - Concentration (LC50) multiplied by the time (t) of exposure that is lethal to 50% of exposed personnel. Usually expressed in minutes of exposure.

  9. SAFETY FACTOR - Ratio between the lethal and incapacitating dose of an agent (LCT50/ICT50). CN: IC50 = 20 milligrams per minute / cubic meter of air. LC50 = 14,000 milligrams per minute / cubic meter of air SAFETY FACTOR OF 700 CS: IC50 = 20 milligrams per minute / cubic meter of air. LC50 = 25,000 milligrams per minute / cubic meter of air SAFETY FACTOR OF 1,250

  10. LCT50 Calculators

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