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Non Barbiturates Hypnotic Agents. Vicente Gonzalez CRNA, MS Assistant Professor Florida International University. OBJECTIVES. Explain the mechanism of action of nonbarbiturate IV anesthetics. Discuss the pharmacokinetic properties of propofol, ketamine, and etomidate.

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non barbiturates hypnotic agents

Non Barbiturates Hypnotic Agents

Vicente Gonzalez CRNA, MS

Assistant Professor

Florida International University

objectives
OBJECTIVES
  • Explain the mechanism of action of nonbarbiturate IV anesthetics.
  • Discuss the pharmacokinetic properties of propofol, ketamine, and etomidate.
  • Compare the effects that nonbarbiturate IV anesthetics have on organ systems.
objectives3
OBJECTIVES
  • Discuss clinical uses of propofol, ketamine, and etomidate.
  • State specific contraindications of nonbarbiturate IV anesthetics in the clinical setting.
  • List potential side effects associated with nonbarbiturate IV anesthetics.
references
REFERENCES

Morgan, G.E., Mikhail, M.S., and Murray, M.J. (2006).

Clinical Anesthesiology. (4th Ed.) New York, NY:

McGraw-Hill.

Nagelhout, J.J. and Naglaniczny, K.L. (2005). NurseAnesthesia. (3rd Ed.) St. Louis, MO: Elsevier-Saunders

references5
REFERENCES

Stoelting, R.K. (2006). Pharmacology & Physiology in

Anesthesia Practice. (4th Ed.) Philadelphia, PA:

J.B. Lippincott Company.

non barbiturate agents
Non barbiturate Agents
  • Agents
  • Uses
  • PK-PD
  • Effects on Organ Systems
  • Induction Doses
  • Contraindications
non barbiturate agents7
Non barbiturate Agents
  • Propofol
  • Etomidate
  • Ketamine
non barbiturate agents8
Non barbiturate Agents
  • Propofol
  • Chemical Structure
  • Commercial Preparations
  • MOA
non barbiturate agents9
Non barbiturate Agents
  • Chemical structure of propofol
non barbiturate agents10
Non barbiturate Agents
  • Propofol cont’d.
  • Pharmacokinetics
  • Clinical Uses
  • Other Uses
non barbiturate agents11
Non barbiturate Agents
  • Propofol cont’d
  • Organ System Effects
    • CNS
    • Cardiovascular
    • Respiratory
    • Renal/Hepatic
non barbiturate agents12
Non barbiturate Agents
  • Propofol cont’d
  • Contraindications
non barbiturate agents13
Non barbiturate Agents
  • ETOMIDATE
  • Chemical Structure
  • Commercial Preparations
  • MOA
non barbiturate agents14
Non barbiturate Agents
  • Chemical Structure of Etomidate
non barbiturate agents15
Non barbiturate Agents
  • Etomidate cont’d
  • Pharmacokinetics
  • Clinical Uses
  • Other Uses
non barbiturate agents16
Non barbiturate Agents
  • Etomidate cont’d
  • Organ System Effects
    • CNS
    • Cardiovascular
    • Respiratory
    • Renal/Hepatic
    • Other
non barbiturate agents17
Non barbiturate Agents
  • Etomidate’s pathway of inhibition of cortisol and other corticosteroids
non barbiturate agents18
Non barbiturate Agents
  • Etomidate cont’d
  • Contraindications
non barbiturate agents19
Non barbiturate Agents
  • Ketamine
  • Chemical Structure
  • Commercial Preparations
  • MOA
non barbiturate agents20
Non barbiturate Agents
  • Chemical Structure of Ketamine
non barbiturate agents21
Non barbiturate Agents
  • Ketamine cont’d
  • Pharmacokinetics
  • Clinical Uses
  • Other Uses
non barbiturate agents22
Non barbiturate Agents
  • Ketamine cont’d
  • Organ System Effects
    • CNS
    • Cardiovascular
    • Respiratory
    • Renal/Hepatic
    • Other
non barbiturate agents23
Non barbiturate Agents
  • Ketamine cont’d
  • Contraindications