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Biodegradable vs. Biodurable Polymers in Drug Delivery

The development of polymer science has significantly influenced drug delivery systems with the discovery of biodegradable and biodurable polymers.<br><br>

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Biodegradable vs. Biodurable Polymers in Drug Delivery

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  1. Biodegradable vs. Biodurable Polymers in Drug Delivery

  2. 1. Knowing Biodegradable Polymers Biodegradable polymers are material substances that, through biological processes, degrade into nontoxic by-products within a given period of time. Typical examples of such polymers are poly(lactic acid) and poly(glycolic acid). In medical applications, especially, these polymers are preferred because they are biocompatible and eventually degrade into harmless products such as water and carbon dioxide.

  3. 2. Characteristics of Biodegradable Polymers Controlled Drug Release: Biodegradable polymers can be fabricated to degrade at specific rates and thereby release their payload of therapeutic agents at controlled rates, thus improving the efficacy of treatments of chronic diseases. Targeted Delivery: The vectors can be designed targeting a tissue or a cell type. This minimizes off-target effects and leads to better patient outcomes.

  4. 3. Understanding Biodurable Polymers By contrast, biodurable polymers are designed to resist biological breakdown and to remain in the body for extended time spans while still being biocompatible. These polymers will not readily degrade in the body but, over time, will be eliminated by the body. Long-term implantable medical devices or tissue engineering scaffolds that provide structural support for a period of time constitute common applications for biodurable polymers.

  5. 4. Key Characteristics of Biodurable Polymers Long-term use: Biodurable polymers can maintain their structural integrity over a very prolonged period, thus providing conditions to maintain support in applications for which such a factor is important.

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