Putting genetic interactions in context through a global modular decomposition . Jamal. Motivation. Genetic interaction provide powerful perspective how gene functions specific mechanisms that give rise to these interactions not well understood
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“Multiple genetic perturbations whose combination result in a phenotype that is unexpected given the phenotypes of the individual perturbations”
The redundancies and dependencies within genetic network can provide powerful means for functional characterization.
MEFIT network is based on coexpression data and does not use genetic interaction datasets