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Enhancing Diclofenac Penetration Through Niosome Systems with Span 60 and Cholesterol

This study investigates the influence of a niosome system composed of sodium diclofenac, Span 60, and cholesterol (1:6:6) on the physicochemical properties and penetration efficacy in an HPC-HEC gel matrix (0.5:0.5). Using SPSS 15.0 for statistical analysis, we observed significant differences in penetration characteristics, specifically flux and permeability, between different formulations. Notably, the niosome system significantly enhanced the penetration of sodium diclofenac, indicating its potential for improved topical delivery.

erasmus-lopez
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Enhancing Diclofenac Penetration Through Niosome Systems with Span 60 and Cholesterol

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  1. ABSTRACT THE INFLUENCE OF NIOSOM SYSTEM (SPAN 60COLESTEROL) ON PREPARATION CHARACTERISTICS AND DICLOFENAC NATRIUM PENETRATION OF HPC-HEC GEL BASED Ertha Kusuma Dewi Natrium diclofenac was a potential NSAIDs. The present study was designed to investigate the effect of niosom system natrium diclofenac-Span 60cholesterol (1:6:6) addition on physicochemical characteristics and natrium diclofenac penetration of HPC-HEC (0,5:0,5) gel based. The result of natrium diclofenac penetration study is flux and permeability. Flux is the cumulative amount of natrium diclofenac which is penetrated per cm2 per minute. It was analyzed by statistic programmed of SPSS 15.0 using one way analysis of variance. The result showed that there was a significant difference between formula I, formula II or formula III. Flux of formula I, formula II and formula III were 0,5236 ± 0,04229 µg/cm2/minute; 0,9053 ± 0,08887 µg/cm2/minute; 1,0982 ± 0,08302 µg/cm2/minute, respectively. Permeability of formula I, formula II, formula III were 5,4015 x 10-5 ± 4,36198 x 10-6 cm/minute; 9,0541 x 10-5±,88956 x 10-6 cm/minute; 1,1432 x 10-4 ± 8,64006 x 10-6 cm/minute, respectively. In the conclusion that niosom system increase the penetration of natrium diclofenac. Keyword (s) : natrium diclofenac, niosom, Span 60, hydroxypropylcellulose, hydroxyethylcellulose, flux, permeability

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