SCARLET FEVER. Definition Etiology Epidemiology Pathogenesis and pathology Clinical manifestation Laboratory findings Complications Diagnosis and Different Diagnosis Treatment Prevention. DEFINITION. Hemolytic streptococcus B group A Acute respiratory infectious disease
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Pathogenesis and pathology
Diagnosis and Different Diagnosis
1.LTA (lipoteichoic acid):adherence to epithelial cells.
2.Erythrogenic toxin:fever,rash and others
3.Strptokinase:resolve clot,protect blood from coagulation.
4.Hyaluronidase:extension in tissue,resolve hyaluronid.
5. M protein :toxic to WBC and PLT
patients and carriers pharyngitis—major source
air-borne: respiratory tract
wound,birth caral-surgical and puerperal type.
after infection of group A streptococcus, two Ab produce.antibacterial Ab-type specific no cross reaction,antitoxic Ab-five serotype persist no crass reaction
1.season:every season,winter and spiring
2.age: every age,children
3.distribution of district
Change of disease
LTA adhere to epithelial cells and go into tissue
M protein resists phagocytosis(facilitate)
Hyaluronidase,streptokinase and hemolysins result in extension of inflammation and tissue necrosis
erythrogenic toxin and other substances-
general toxic symptoms:fever, headache and bad appeptite,
signs:hepatomegaly and splenomegaly lymphonode fatty degeneration and congestion,myocardia and kidney injury.
2)Pharyngitis:red exudation sore
3)Rash:24h after fever,diffuse erythema,1mm,pastauricular-neck-chest-limbs
4)companied signs:circumoral pallor,pastia’s lines,raspberry tongue-strawberry tongue.
Primary septic site or transmission site or no pharyngitis or pathogen
using drug or no pharygitis or relieve after stopping or pathogen
sever or liver and kidney injury-shock or pathogen
Isolation 7 days, temperature, puls, BP, glucose, liquid
penicillin or erythromycin or cefotomycin
adult: 5-7d; child: 10d
mask,disinfect to secrations and infection substances