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Evo-Devo : Evolutionary Development. DNA Regulatory genes : code for signal proteins and transcription factor proteins SP: target particular groups of cells for gene expression Regulatory sequences : binding sites of transcription factors (enhancers, promoters).

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Evo-Devo : Evolutionary Development


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    1. Evo-Devo: Evolutionary Development • DNA • Regulatory genes: code for signal proteins and transcription factor proteins • SP: target particular groups of cells for gene expression • Regulatory sequences: binding sites of transcription factors (enhancers, promoters). • Structural genes: Activated by binding of TF & RS • Responsible for producing phenotypic characters.

    2. Dll expression En/Inv expression Eyespots on a butterfly wing

    3. Homeotic Genes and Animal Body Plans • Multicellular animals develop in four dimensions. • 3 spatial + time • Each cell has to have • 1. information: where it is relative to other cells • 2. where it is in the developmental sequence. • Information provided by Homeotic genes (Hox genes)

    4. Cells along these major body axes assume positional information during development (After Strickberger.)

    5. Hox genes in Drosophila (body segmentation) Positional information Colinearity: 1. Expressed first 2. Anterior to posterior 3. Greater quantity of transcription factors Gene location in hox cluster

    6. Colinear Hox gene expression • Hox genes provide information on location. • 1. The transcription factor from the first Hox gene • required to express downstream Hox genes. • 2. The effectiveness in initiating sequential gene expression declines with distance. Paralogous and evolutionarily conserved

    7. Each Hox gene contains a highly conserved 180 bp sequence – the homeobox. Codes for a DNA binding segment (aa sequence) in the transcription factor. The transcription factors activate structural genes. Structural genes produce structures appropriate for that location. Mutations in Hox genes result in inappropriate structures for that location.

    8. Hox gene products activate genes responsible for making a particular structure. Mutations in Hox genes bx, pbx, and abx Mutation of Hox gene antp Wings normally appear on T2 Hox mutations change identity of T3 cells to T2 cells. An extra pair of wings is produced. Ancestors of dipteran flies had 4 wings. Identity of a head segment changed to that of a thoracic segment

    9. Hox gene diversification  diversification of animals • Hox paraloges (homologs): in everything from SpongeBob Squarepants to humans to fungi and plants (MADS-box genes). • Therefore, Homeoboxgenes predate the origin of animals.

    10. Representative arthropods: What is the basis of their diversity? • 1 million sp. described; maybe 50 million still to be named. • Exoskeleton; segmented body (H –T – A) and segmented legs • Paired appendages on body segments; open circulatory system Crustaceans Hexapods Myriapods An onychophoran (velvet worm) Closest living relative of arthropods 1 pr. unjointed legs on each of the similar body segments Chilicerates

    11. Evolutionary diversification of arthropods partly based on sites of Hox gene expression Hox cluster of 9 loci for all arthropods abdA always expressed on ventral side of segment Ubx and abdA not expressed in posterior segments Evolutionary change in where a Hox gene is expressed Mutation: legless abdominal segments

    12. Homeotic genes and Flower formation C. 300,000 sps. of Angiosperms Four concentric whorls of modified leaves Normal order: sepals, petals, stamens, carpels

    13. MADS-box mutants (Hox genes)