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  1. Dommages et réparation de l’ADN Causes de dommages Radio etchimiothérapie Erreurs de réplication Agents alkylants Radicaux O2Rayons-X UV Types de dommages Cassure Double-brins Adduits Insertionsdélétions Ox-alkylguanine Cassure mono-brin NHEJHRR XP polyméraseExcision de Nucléotides MSH2 MLH1 Mésappariement des bases (MMR) AGTRéversion directe(AGT) PARPExcision de base Enzymes de réparation ERCC1 ASCO GI 2011 - D’après Curtin NJ et al., General session II