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SURVEY OF BIOCHEMISTRY Glycogen. 2 Ways To Generate Glucose. Glycogenolysis. Gluconeogenesis. Break down of glycogen. Synthesis of glucose from non-carb precursors. Glucose 1-Phosphate. Glucose. Pyruvate. Lactate. Glucose 6-Phosphate. Energetics of Reversing Glycolysis.

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Presentation Transcript
2 ways to generate glucose
2 Ways To Generate Glucose

Glycogenolysis

Gluconeogenesis

Break down of glycogen

Synthesis of glucose fromnon-carb precursors

Glucose1-Phosphate

Glucose

Pyruvate

Lactate

Glucose 6-Phosphate

energetics of reversing glycolysis
Energetics of Reversing Glycolysis

Reversing glycolysis is not energetically feasible!

Hexokinase ∆G° = -17 kJ/mol

Glucose

Phosphofructokinase ∆G° = -14 kJ/mol

PyruvateKinase ∆G° = -31 kJ/mol

Pyruvate

Ref: Rodney Boyer Interactive Concepts in Biochemistry

pyruvate to phosphoenolpyruvate
Pyruvate to Phosphoenolpyruvate
  • Dilemma:
  • Oxaloacetate can only be generated from pyruvate in the mitochondria
  • Pyruvate gets synthesized initially in the cytosol
pep and oxaloacetate transport
PEP and Oxaloacetate Transport

Fig 16-20 does not show pyruvate!

Draw another viewof this process thatmay be more helpful

energetics revisited
Energetics Revisited

∆G value comparisons

By what mechanisms do these enzymes work?

ch 16 overview
Ch. 16 Overview
  • 16-1 Glycogen Breakdown (Fri)
  • 16-2 Glycogen Synthesis (Wed)
  • 16-3 Control of Glycogen Metabolism (Wed)
  • 16-4 Gluconeogenesis (Mon)
enzymes in glycogen synthesis
Enzymes in Glycogen Synthesis
  • UDP-Glucose Pyrophosphorylase
  • Glycogen Synthase
  • Glycogen Branching Enzyme
udp glucose pyrophosphorylase
UDP-Glucose Pyrophosphorylase

UDP-GlucosePyrophosphorylase

activates glucosylunits

PPi

slide19
PRS
  • Which of the following enzymes is involved in gluconeogenesis?
  • Pyruvate carboxylase
  • Pyruvate kinase
  • Phosphofructokinase
  • Glycogen synthase
slide20
PRS
  • Which of the following is not a product of glycolysis?
  • Pyruvate
  • Fructose 1,6-Bisphosphate
  • Oxaloacetate
  • Glucose 6-Phosphate
slide21
PRS
  • Which enzyme produces glucose 1-phosphate?
  • Hexokinase
  • Glycogen Debranching Enzyme
  • Glycoen Branching Enzyme
  • Glycogen Phosphorylase