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Oxygen Transport

0.3 ml O 2 in solution in plasma 1.5%. 19.5 ml O 2 bound to Hb 98.5%. Oxygen Transport. Systemic arterial blood contains: ~19.8 ml O 2 /100 ml blood. Respiratory Pigments. Protein, containing a metal, with or without a prosthetic group Increases the O 2 -carrying capacity of the blood

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Oxygen Transport

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  1. 0.3 ml O2 in solution in plasma 1.5% 19.5 ml O2 bound to Hb 98.5% Oxygen Transport Systemic arterial blood contains: ~19.8 ml O2/100 ml blood

  2. Respiratory Pigments • Protein, containing a metal, with or without a prosthetic group • Increases the O2-carrying capacity of the blood • Can function continuously or only at low oxygen tensions • Play other roles besides O2 transport

  3. Common characteristics: • Reversibly bind O2 • Bind O2 with proper affinity

  4. Hemoglobin

  5. Human Hb M.W. = 64,450 4 subunits - 2 a and 2 b each subunit has a porphyrin heme moiety containing one Fe2+ each Fe2+ can bind one O2 Hb + O2 HbO2 HbO4 + O2 HbO6 HbO2 + O2 HbO4 HbO6 + O2 HbO8

  6. P50

  7. Cooperativity Sigmoid shape due to cooperativity in O2 binding sites

  8. Respiratory Pigments Pigment Description M.W. Occurrence Hemoglobin Iron w/ porphyrin 17,000 - Most widely dist. (Hb) 3,000,000 annelids, molluscs arthropods, verts. Chlorocruorin “ 3,400,000 Polychaetes Hemerythrin Iron w/o porphyrin 66,000 - Sipunculids, poly- 120,000 chaetes, priapu- lids,brachiopods Hemocyanin Copper 400,000 - Molluscs, (HCy) 6,680,000 arthropods Hemovanadin Vanadium Tunicates

  9. Bohr Effect - Decrease in O2 affinity (increase in P50) with decrease in pH (increase in [H+])

  10. CO2 effect - decrease in O2 affinity with an increase in PCO2

  11. Temperature effect - decrease in O2affinity with an increase in temp.

  12. pH 7.4 100 pH 6.8 % Saturation 0 0 160 PO2 (mm Hg) Root Effect - Fish hemoglobin demonstrates a decrease in O2-carrying capacity with a decrease in pH

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