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Annette Thomas, RN, MS, PhD student Nancy Fugate Woods, PhD, RN, FAAN Ellen Sullivan Mitchell, PhD

Soy, Isoflavones , and Amino Acids for Symptom Clusters During the Menopausal Transition and Early Postmenopause : A Systematic Review. Annette Thomas, RN, MS, PhD student Nancy Fugate Woods, PhD, RN, FAAN Ellen Sullivan Mitchell, PhD Janet Schnall MS, AHIIP. Background.

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Annette Thomas, RN, MS, PhD student Nancy Fugate Woods, PhD, RN, FAAN Ellen Sullivan Mitchell, PhD

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  1. Soy, Isoflavones, and Amino Acids for Symptom Clusters During the Menopausal Transition and Early Postmenopause: A Systematic Review Annette Thomas, RN, MS, PhD student Nancy Fugate Woods, PhD, RN, FAAN Ellen Sullivan Mitchell, PhD Janet Schnall MS, AHIIP

  2. Background • Women have been reluctant to use HT since the publication of the WHI results and increasingly have become interested in CAM therapies • Soy & Isoflavones may be a good alternative for women who experience Hot Flashes as well as other associated symptoms such as problems with cognition, sleep, mood, or pain.

  3. Background

  4. Aim To review controlled clinical trials of Soy, Isoflavones, and Amino Acids on hot flashes and at least one other symptom that women experience during the menopausal transition (MT) and post menopause (PM) such as problems with sleep, cognitive function, mood, and pain

  5. Methods Of the 59 unique trials identified of nonpharmacologic therapies, 17 Soy, Isoflavone, & Amino Acid RCTs were systematically reviewed: 5 Soy protein 7 Isoflavone 2 Amino Acid 3 Mixtures

  6. Results… Soy Protein

  7. Results… Isoflavones

  8. Results… Isoflavones (cont’d) Key: + is significant for P<=0.05 or better NS is Not Significant NM is Not Measured

  9. Results… Amino Acids

  10. Results… Mixtures Key: EP= Equol producers, Non-EP= Non Equol Producers, N-30= Non Equol Producers taking 30mg Equol

  11. Conclusion • Of all the studies, Rexflavone (135mg) demonstrated significant treatment effects for all categories • The soy protein category showed significant treatment effects for hot flashes and moodsymtpoms • Isoflavones significantly improved hot flashes, sleep, mood, and pain symptoms • Of the symptoms studied, soy andisoflavonetherapiesmost frequently improved hot flashes and mood and had the least effect on cognitive functions • Recommendations for future research is to include symptom cluster categories, more cognitive function studies, and classification into EP vs. Non-EP women.

  12. Acknowledgement The Nursing Scholarship Foundation of The University of Washington School of Nursing Data were collected with support from grants from the National Institute for Nursing Research, NIH, NR01 04141 and NINR, NIH, P50-NR-02323, P30-NR04001

  13. Thank You

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