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Putting Proteins in Context: The Transition From Structure to Function

Putting Proteins in Context: The Transition From Structure to Function. Interaction. Most proteins function by binding. Factors Bound by Different Protein Classes . Transport - O 2 /CO 2 , cholesterol, metals, sugars Storage - metals, amino acids, Immune response - foreign matter (antigens)

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Putting Proteins in Context: The Transition From Structure to Function

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  1. Putting Proteins in Context: The Transition From Structure to Function Interaction • Most proteins function by binding

  2. Factors Bound by Different Protein Classes • Transport- O2/CO2, cholesterol, metals, sugars • Storage- metals, amino acids, • Immune response- foreign matter (antigens) • Receptors- regulatory proteins, transmitters • Structure- other structural proteins • Enzymes- substrates, inhibitors, co-factors • Toxins- receptors • Cell functions- proteins, metals, ions

  3. Surface Properties Determine What Binds • Steric access • Shape • Hydrophobic accessible surface • Electrostatic surface Sequence and structure optimized to generate consequent surface properties for requisite binding event(s)

  4. Binding: Progression and Regulation • Allosteric Control- binding at one site effects changes in conformation or chemistry at a point distant in space • Stimulation/inhibition by control factors- proteins, ions, metals control progression of a biochemical process (e.g. controlling access to active site) • Reversible covalent modification- chemical bonding, e.g. phosphorylation (kinase/phosphatase) • Proteolytic activation/inactivation- irreversible, involves cleavage of one or more peptide bonds

  5. Ca2+ Target Calcium Signal Transduction

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