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Understanding Genetic Linkage: Analysis of Test Cross Data

This study guide provides a comprehensive overview of genetic linkage, including definitions and key concepts. Students will learn the meanings of parental and recombinant types, and from test cross data, they will deduce whether two genes are likely linked. The content focuses on identifying parental and recombinant classes in provided genetic scenarios, helping students understand how gene proximity on chromosomes affects phenotypic ratios. Included are practice problems to reinforce learning of these concepts as seen in genetics literature.

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Understanding Genetic Linkage: Analysis of Test Cross Data

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  1. Students will be able to: • explain what is meant by “genetic linkage” • understand the meaning of parental and recombinant types • from testcross data: • deduce whether two genes are likely to be linked • identify parental and recombinant classes

  2. 5 The American Journal of Human Genetics 82, 150–159, January 2008 3 4 1 2

  3. w+ m+ w- m- X In the testcross below, what fraction of flies will be white-eyed, long winged? w+ m+ w- m- white eyes short wings red eyes long wings w- m- w+ m+ X w- m- w- m- white, short red, long A. 3/4 B. ¼ C. ½. D. 0 white, long

  4. If w and m are located near each other on the chromosome, how will that change the proportion? w+ w- m- m+ X w+ w- m+ m- white eyes short wings red eyes long wings w+ w- m- m+ X w- w- m- m- white, short red, long ? white, long

  5. Identify parental and recombinant classes CC shsh cc ShSh X colored, shrunken white, plump Cc Shsh cc shsh X colored, plump white, shrunken colored plump white shrunken

  6. What are the parental/recombinant genotypes? X CC shsh cc ShSh colored, shrunken white, plump X Cc Shsh cc shsh colored, plump white, shrunken

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