Antioxidants in Dermatology Oxidative stress and free oxygen radicals are responsible for ageing, photoageing and skincancer. Antioxidants are therefore used to treat or prevent tissue damage caused byoxidative stress. Commonly available antioxidants are Vit E and Vit C. Other newer agents have been extensively studied for their antioxidant properties. GLUTATHIONE: It is the body’s master antioxidant. It is said to be important in maintaining good health. Aperson exposed to toxins is said to have a lower level of glutathione than normal population,hence, cells die at a faster rate leading to quicker ageing and senisense. It protects the skinfrom sun and environmental damages and lightens skin colour and pigmentation. Depletionof glutathione is seen with smoking, alcohol consumption, caffeine, drug use and excess UVexposure; hence the skin looks aged in the people with above behavioural symptoms(smokers, alcoholics and drug abusers, etc.). TOPICAL VITAMIN E (Alpha-tocopherol): Mechanism of action: It acts by protection of cell membrane and as a free radicalscavenger. Indications: Reduction in wrinkling
Reduction in roughness associated with skin damage to sun exposure Used as a component of sunscreen It helps in wound healing TOPICAL VITAMIN C (Ascorbic Acid):Mechanism of action: It acts by protection of skin from UV damage caused by prolonged sun exposure by reducing the amount of free radical formation / sun burn cells Collagen biosynthesis pathway by activating collagen metabolism and increased synthesis of elastic fibres Vitamin C has some role to play in pigmentary disorders by reducing melanin synthesis Indications: In the treatment of fine lines and wrinkles (anti-ageing) Wound healing by increasing collagen synthesis Decreased severity of sun burns Decrease in pigmentationNewer Antioxidants: a) Licorice (botanical name is Glycyrrhiza glabra)Mechanism of action: Inhibits melanin synthesis Inhibits formation of superoxide / free radical formation b) Isoflavone genistein: It is a newer antioxidant rich in flavanoidsMechanism of action: Antioxidant agent Anticancer agent Photoprotective agent c) Green Tea Obtained by steaming and drying of the fresh leaves of the tea plant, camellia sinensis. Green tea has antioxidant, photoprotective, anti-inflammatory and anticancer properties.
d) Ubiquinone Naturally occurring antioxidant in the skin. Mechanism of action: Combats free radicals. These newer agents are the latest in field of cosmeceuticals and are a highly researched subject. Article Source http://www.skinclinicbangalore.com/post/antioxidants-in-dermatology/1422Published at Dr. Kisalay Saurav’s blog