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Mineralogy of Bone: Effects on Osteoporosis

Explore the mineral content of bones, their crystal chemistry and structure, and its relationship to osteoporosis. Discover how changing minerals and environmental factors impact bone density and learn about focused treatments for osteoporosis.

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Mineralogy of Bone: Effects on Osteoporosis

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  1. Mineralogy of Bone And its effects OsteoporosisBy Vanessa Rutherford

  2. Introduction • The body and the environment around it • React to exposure of natural and man-made chemicals • Discussion of • The bones/their mineral content • Crystal chemistry and structure • Analysis of Bone • Osteoporosis

  3. Mineralized Tissues • Calcium phosphate hydroxylapatite • Normal mineralized tissues: • Teeth (enamel, dentine & cementum) • Bone • Pathological mineralization • Tumors, scar tissue, arteries, kidneys, dental calculus.

  4. Composition of Mineralized Tissues

  5. Changing Minerals • Hexagonal structure of bioapatites can bind to compounds other than calcium • Lead • Gasoline, uranium, soil, leaded paint • Florine (fluoride in water) • Composition changes • Age • Geographical location • Ingestion of food and water

  6. Osteoporosis is? Apparent Density • Normal mineral/collagen ratio • Decreased mineral tissue per unit area • Influenced by environmental factors

  7. Osteoporosis Detection • Mineral concentration per mass of bone is measured. • Porous bone

  8. Osteoporosis Mineral Focused Treatments • Fluoride • May affect bone cells and the formation of the organic matrix. • Narrow therapeutic window • Bisphosphonates • Prevents resorption of calcium phosphates by osteoclast cells to prevent dissolution of bioapatite. • May cause osteoclast apoptosis • Hormones • Estrogen • Important in keeping calcium levels adequate for proper skeletal mineralization.

  9. Conclusion • Mineralized tissues play a role in growth development and maintenance of all bodily functions, organs, and tissues. • Bioapatite as a record keeper of chemicals ingested and our environments. Three forward!

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