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Bone Biology and Osteoporosis: Back to the Basics

Bone Biology and Osteoporosis: Back to the Basics. Learning Objectives. Who Is at Risk for Osteoporosis?. Most Women With Hip Fractures Do Not Have a T score ≤ -2.5. FRAX. FRAX Clinical Risk Factors. Who Should Be Treated?.

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Bone Biology and Osteoporosis: Back to the Basics

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  1. Bone Biology and Osteoporosis: Back to the Basics

  2. Learning Objectives

  3. Who Is at Risk for Osteoporosis?

  4. Most Women With Hip Fractures Do Not Have a T score ≤ -2.5

  5. FRAX

  6. FRAX Clinical Risk Factors

  7. Who Should Be Treated?

  8. RANKL Is Implicated in Bone Loss Across a Broad Range of Conditions

  9. Potential Strategies for Downregulating RANKL

  10. Wnt Signaling Pathway

  11. Inhibition of Sclerostin Stimulates Bone Formation

  12. PTH Inhibits Sclerostin andStimulates Bone Formation

  13. Inhibition of Cathepsin K Inhibits Bone Resorption

  14. Individualizing Treatment Decisions

  15. Individual Patient Factors

  16. Clinical Challenges After Starting Treatment

  17. Summary

  18. Abbreviations

  19. Abbreviations (cont)

  20. References

  21. References (cont)

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