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Effects of Osteoporosis Treatments. Angela Dowdle Max Rosen Jennifer Sauer Alex Uhrich. Meet Maxine…. Maxine is a 72-year old woman who was formally very active until the onset of excruciating pain between her shoulder blades

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Effects of osteoporosis treatments l.jpg

Effects of Osteoporosis Treatments

Angela Dowdle

Max Rosen

Jennifer Sauer

Alex Uhrich


Meet maxine l.jpg
Meet Maxine…

  • Maxine is a 72-year old woman who was formally very active until the onset of excruciating pain between her shoulder blades

  • She saw her doctor once the pain was bad enough to prevent her from performing normal activities

  • Her doctor diagnosed osteoporosis, and must consider the different types of treatments…


Healthy bone l.jpg
Healthy Bone

  • Dynamic bone deposition and resorption

  • Osteoblasts

    • Derived from stromal cells

    • Secrete organic bone matrix (osteoid)

    • Quantity tend to decrease as people age

  • Osteoclasts

    • Derived from macrophage cells

    • Remove mineralized matrix, break up organic matrix

    • Regulated by parathyroid hormone, calcitonin and several moleculessecreted by osteoblasts

      • These may all decrease with aging


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Progression to Osteoporosis

  • Disruption in osteoblast and osteoclast activity leads to bone density problems

  • Osteopenia

    • Lower than normal peak BMD

    • Precursor to osteoporosis

  • Osteoporosis

    • Osteoclasts carve too deeply

    • Osteoblasts fail to fill enough bone back in

    • Fragility; vulnerability


Osteoporosis treatments l.jpg
Osteoporosis Treatments

  • Estrogen/Progesterone Hormone Replacement Therapy

    • Preventive; makes up for declining hormone concentrations in elderly

  • Raloxifene

    • Preventive; binds to estrogen receptors, mimics normal function

  • Bisphosphonates

    • Bind to calcium hydroxyapatite; inhibit osteoclastic activity

  • Parathyroid Hormone

    • Increases bone mass by preventing apoptosis of osteoblasts; also enhances formation of gap junctions

  • Osteoprotegerin

    • Inhibits formation of osteoclasts



Bibliography l.jpg
Bibliography

ABC Health and Wellbeing (2004). Retrieved from http://www.abc.net.au/health/library/img/osteoporosis_diag.jpg

Amazing tsunami picture, (2010). [Web]. Retrieved from http://images.google.com/imgres?imgurl=http://z.about.com/d/urbanlegends/1/0/T/5/tsunami_sm.jpg&imgrefurl=http://urbanlegends.about.com/library/bl_tsunami_picture.htm&usg=__YuTXECYxQDBojNtUEmaR41LtJok=&h=354&w=375&sz=30&hl=en&start=2&um=1&itbs=1&tbnid=wy0XzdLw-eX-9M:&tbnh=115&tbnw=122&prev=/images%3Fq%3Dtsunami%26um%3D1%26hl%3Den%26safe%3Doff%26sa%3DN%26tbs%3Disch:1

Jilk, R.L., Weinstein, R.S., Bellido, T., Roberson, P. et al. (1999). Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. JCI, 104: 439-446.

MedicineNet. (2001, January 30). Definition of calcitonin. Retrieved from http://www.medterms.com/script/main/art.asp?articlekey=16051

National Osteoporosis Foundation (2008). Osteoporosis: a debilitating disease that can be prevented and treated. Retrieved from http://www.nof.org/osteoporosis/index.htm

Rosen, C.J. (2003). Restoring aging bones. Scientific American, 288 (3): 71-77.

WebMD (2008, November 21). Osteopenia - overview. Retrieved from http://www.webmd.com/osteoporosis/tc/osteopenia-overview


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