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Japanese Approach to colon cancer and the Outcome. Kenichi Sugihara. Dep. of Surgical Oncology Tokyo Medical and Dental University. Overall Survival. 1997 〜 2000 in 18 hospitals. 1.0. 84.6%. Colon Ca (n=3061). 0.8. P = 0.0033. Survival rate. 80.6%. 0.6. Rectal Ca (n=1393).

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japanese approach to colon cancer and the outcome
Japanese Approach to colon cancer and the Outcome

Kenichi Sugihara

Dep. of Surgical Oncology

Tokyo Medical and Dental University

overall survival
Overall Survival

1997 〜 2000 in 18 hospitals

1.0

84.6%

Colon Ca(n=3061)

0.8

P = 0.0033

Survival rate

80.6%

0.6

Rectal Ca(n=1393)

0.4

0.2

median follow-up time: 71 months

0.0

0

1

2

3

4

5

6

7

8

9

10

year

os stage ii colon cancer
OS; Stage II Colon Cancer

TNM 7th ed.

N 5Y-OS

800, 93.5%

914, 88.8%

195, 81.7%

92, 82.1%

128, 91.3%

743, 77.4%

189, 55.5%

1.0

Stage I

0.8

Stage IIA

Survival rate

Stage IIB

0.6

Stage IIC

0.4

Stage IIIA

0.2

Stage IIIB

P<0.0001

Stage IIIC

0.0

0

1

2

3

4

5

6

7

8

9

10

year

os stage iii colon cancer
OS; Stage III Colon Cancer

TNM 7th ed.

N 5Y-OS

800, 93.5%

914, 88.8%

195, 81.7%

92, 82.1%

128, 91.3%

743, 77.4%

189, 55.5%

1.0

Stage I

0.8

Stage IIA

Survival rate

Stage IIB

0.6

Stage IIC

0.4

Stage IIIA

0.2

Stage IIIB

P<0.0001

Stage IIIC

0.0

0

1

2

3

4

5

6

7

8

9

10

year

slide6

UFT/LV vs. 5FU/LVJCOG 0205: Phase III non-inferiority study

StageIII

Colon Cancer

(n=1,101)

R

UFT/LV(oral) (n=551)

5FU/LV(RPMI) (n=550)

Feb. 2003 - Oct. 2006

Primary endpoint:DFS

Secondary endpoint:OS, Safety

Disease Free Survival

Overall Survival

94.2%

90.3 %

88.2 %

78.3 %

75.0 %

73.8 %

mortality morbidity
Mortality/Morbidity

National Survey of Digestive Surgery

by the Japanese Society of Gastroenterological Surgery

1,191,643surgeries between 2006 and 2008

No.

Mortality

118,426

Surgery of Colon Cancer

0.7%

high/low anterior resection

55,557

0.34%

APR

11908

0.7%

Anastomotic

Leakage

No.

39,386

rt. colectomy/hemicolectomy

1.5%

high anterior resection

17,418

2.5%

d ifferences of colon cancer care between japan and western
Differences of Colon Cancer Carebetween Japan and Western
  • Scope of LN dissection
  • Histopathologicalexamination
  • of resected specimens
  • Surveillance after surgery
  • Strategy for liver metastasis
  • Medical care system/Medical insurance system

JSCCR