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Learning Set 3 : Lesson 1 : Slide 1

Proteins Move Based on Size. lactase. tyrosinase. Learning Set 3 : Lesson 1 : Slide 1. Analyzing LDL receptor . A. B. C. LDL receptor. Why did these LDL receptor proteins move farther down the columns?. Normal LDL Receptors. George’s LDL Receptors. Learning Set 3 : Lesson 1 : Slide 2.

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Learning Set 3 : Lesson 1 : Slide 1

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  1. Proteins Move Based on Size lactase tyrosinase Learning Set 3 : Lesson 1 : Slide 1

  2. Analyzing LDL receptor A B C LDL receptor Why did these LDL receptor proteins move farther down the columns? Normal LDL Receptors George’s LDL Receptors Learning Set 3 : Lesson 1 : Slide 2

  3. What Is The Difference Here? Sequence of amino acids in LDL receptor protein: Column A MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDV Column B VCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDV Column C MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTK Learning Set 3 : Lesson 1 : Slide 3

  4. DNA Location Learning Set 3 : Lesson 2 : Slide 4

  5. Click Here Chromosomes Learning Set 3 : Lesson 2 : Slide 5

  6. Pieces to DNA Model 6 T (Orange) 6 A (Blue) 6 G (Green) 6 C (Yellow) 12 spacers (transparent) 1 cap (white) 1 base (light brown) 1 rod (grey) of alternating deoxyribose (red) and phosphate (purple) 2 side chains composed Learning Set 3 : Lesson 3 : Slide 6

  7. DNA Base Pairs Learning Set 3 : Lesson 3 : Slide 7

  8. Pieces to LDL Receptor Protein DNA Model Learning Set 3 : Lesson 3 : Slide 8

  9. Marshmallow Color Key Learning Set 3 : Lesson 3 : Slide 9

  10. Step by Step Pictures Step #1: Learning Set 3 : Lesson 3 : Slide 10

  11. Step by Step Pictures (cont.) Step #2: Learning Set 3: Lesson 3: Slide 11

  12. Step by Step Pictures (cont.) Step #3: Learning Set 3 : Lesson 3 : Slide 12

  13. Chromosomes to DNA to Genes Click Here How small is small? Learning Set 3 : Lesson 4 : Slide 13

  14. From DNA to Proteins Transcription -Translation Learning Set 3 : Lesson 4 : Slide 14

  15. Click Here From DNA to Proteins 1 Transcription & Translation Overview Learning Set 3 : Lesson 4 : Slide 15

  16. Symbols for Transcription -Translation Models Learning Set 3 : Lesson 4 : Slide 16

  17. DNA vs. RNA DNA RNA Learning Set 3 : Lesson 4 : Slide 17

  18. DNA vs mRNA DNA RNA Learning Set 3 : Lesson 4 : Slide 18

  19. Click Here From DNA to Proteins 2 Transcription & Translation Interactive Modeling Learning Set 3 : Lesson 4 : Slide 19

  20. Coding Amino Acids RNA amino acid Learning Set 3 : Lesson 4 : Slide 20

  21. LDL Receptor Learning Set 3 : Lesson 4 : Slide 21

  22. Where are our genes? Learning Set 3 : Lesson 4 : Slide 22

  23. Location of LDL Receptor Gene Learning Set 3 : Lesson 4 : Slide 23

  24. LDL Receptor Gene Segment focused on in class Learning Set 3 : Lesson 3 : Slide 24

  25. Marshmallow DNA Model A C C G C G A C A C Learning Set 3 : Lesson 4 : Slide 25

  26. RNA Marshmallow Color Key Learning Set 3 : Lesson 4: Slide 26

  27. Coding Amino Acids RNA amino acid Learning Set 3 : Lesson 4 : Slide 27

  28. Reviewing George’s Symptoms Familial Hypercholesterolemia (FH) • Very high cholesterol in blood • Waxy patches on the skin • Chest pain and heart attacks at a young age • Build up of fatty deposits on under skin and in arteries Knees and Fingers Coronary Artery: a heart artery Fatty Deposit Fatty Deposit Learning Set 3 : Lesson 5 : Slide 28

  29. George Heart attack: 25y George’s Family History Learning Set 3 : Lesson 5 : Slide 29

  30. Why George had a Heart Attack Cross Section of Coronary Artery Fatty Deposits In Coronary Artery Tear in artery wall Normal Fatty Deposit Fatty deposits made in artery wall Narrowed artery blocked by blood clot • Fatty deposits made in artery wall, high blood pressure • Arteries harden and narrow due to fat accumulation • Blood flow is reduced • Oxygen supply to heart reduced • Can cause chest pain heart attack or death in severe cases Learning Set 3 : Lesson 5 : Slide 30

  31. Cholesterol: Many Roles Cholesterol Estrogen Testosterone Bile Acids Learning Set 3 : Lesson 5 : Slide 31

  32. Low density lipoprotein (LDL) Receptor cholesterol Cholesterol in LDL LDL Receptor outside cell Plasma Membrane cell inside cell Takes LDL into cell nucleus Learning Set 3 : Lesson 5 : Slide 32

  33. LDL Receptor Learning Set 3 : Lesson 5 : Slide 33

  34. Analyzing George’s LDL receptor A B C LDL receptor George’s LDL receptor Learning Set 3 : Lesson 5: Slide 34

  35. Why did Rachel look at George’s DNA? One of George’s chromosomes, chromosome 19, had an arrow pointing at one spot on it. This arrow indicated something was different at this spot on chromosome 19. What does DNA have to do with the LDL receptor that causes FH disease? Learning Set 3 : Lesson 5 : Slide 35

  36. Analyzing the Family’s DNA George Learning Set 3 : Lesson 5 : Slide 36

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